Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions
Epigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodevelopmental diseases, and thus, epigenetic regulatio...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-01-01
|
| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319309545 |
| _version_ | 1818962000709943296 |
|---|---|
| author | Takeo Kubota Kunio Miyake Takae Hirasawa Kaoru Nagai Tsuyoshi Koide |
| author_facet | Takeo Kubota Kunio Miyake Takae Hirasawa Kaoru Nagai Tsuyoshi Koide |
| author_sort | Takeo Kubota |
| collection | DOAJ |
| description | Epigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodevelopmental diseases, and thus, epigenetic regulation is essential for normal brain development. Besides these intrinsic defects, it is becoming increasingly apparent that extrinsic factors, such as insufficient nutrition, psychiatric drugs, and mental stress, also alter epigenetic regulation. Therefore, environmental factors may lead to “acquired” neurodevelopmental disorders through the failure of epigenetic regulation. Epigenetics is a biological key to understand the gene–environment interactions in neurodevelopmental disorders. As the mechanism is reversible, its comprehensive understanding will result in the development of new therapies for these disorders. Keywords:: epigenetics, DNA methylation, brain, environment, neurodevelopmental disorder, neurodisease |
| first_indexed | 2024-12-20T12:22:22Z |
| format | Article |
| id | doaj.art-fc98781be7fb4837b60a720c24e6c968 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-20T12:22:22Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-fc98781be7fb4837b60a720c24e6c9682022-12-21T19:40:56ZengElsevierJournal of Pharmacological Sciences1347-86132010-01-01113138Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment InteractionsTakeo Kubota0Kunio Miyake1Takae Hirasawa2Kaoru Nagai3Tsuyoshi Koide4Department of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan; Corresponding author. takeot@yamanashi.ac.jpDepartment of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, JapanDepartment of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, JapanDepartment of Epigenetics Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, JapanMouse Genomics Resource Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8540, JapanEpigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodevelopmental diseases, and thus, epigenetic regulation is essential for normal brain development. Besides these intrinsic defects, it is becoming increasingly apparent that extrinsic factors, such as insufficient nutrition, psychiatric drugs, and mental stress, also alter epigenetic regulation. Therefore, environmental factors may lead to “acquired” neurodevelopmental disorders through the failure of epigenetic regulation. Epigenetics is a biological key to understand the gene–environment interactions in neurodevelopmental disorders. As the mechanism is reversible, its comprehensive understanding will result in the development of new therapies for these disorders. Keywords:: epigenetics, DNA methylation, brain, environment, neurodevelopmental disorder, neurodiseasehttp://www.sciencedirect.com/science/article/pii/S1347861319309545 |
| spellingShingle | Takeo Kubota Kunio Miyake Takae Hirasawa Kaoru Nagai Tsuyoshi Koide Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions Journal of Pharmacological Sciences |
| title | Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions |
| title_full | Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions |
| title_fullStr | Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions |
| title_full_unstemmed | Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions |
| title_short | Novel Etiological and Therapeutic Strategies for Neurodiseases: Epigenetic Understanding of Gene–Environment Interactions |
| title_sort | novel etiological and therapeutic strategies for neurodiseases epigenetic understanding of gene environment interactions |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319309545 |
| work_keys_str_mv | AT takeokubota noveletiologicalandtherapeuticstrategiesforneurodiseasesepigeneticunderstandingofgeneenvironmentinteractions AT kuniomiyake noveletiologicalandtherapeuticstrategiesforneurodiseasesepigeneticunderstandingofgeneenvironmentinteractions AT takaehirasawa noveletiologicalandtherapeuticstrategiesforneurodiseasesepigeneticunderstandingofgeneenvironmentinteractions AT kaorunagai noveletiologicalandtherapeuticstrategiesforneurodiseasesepigeneticunderstandingofgeneenvironmentinteractions AT tsuyoshikoide noveletiologicalandtherapeuticstrategiesforneurodiseasesepigeneticunderstandingofgeneenvironmentinteractions |