A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility

A Non-Synonymous Point Mutation in a WD-40 Domain Repeat of EML5 Leads to Decreased Bovine Sperm Quality and Fertility

This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-assoc...

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Bibliographic Details
Main Authors: Eriklis Nogueira, Filip Tirpák, Lauren E. Hamilton, Michal Zigo, Karl Kerns, Miriam Sutovsky, JaeWoo Kim, Dietrich Volkmann, Luca Jovine, Jeremy F. Taylor, Robert D. Schnabel, Peter Sutovsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
spermiogenesis
fertilization
acrosomal biogenesis
spermatozoa
SNP
fertility
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.872740/full

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