Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer
The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes the myometrial contraction of labour at term or preterm appears to share some common mechanisms with the occurrence, growth, invasion and metastasis of cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-depe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-08-01
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| Series: | Vascular Biology |
| Subjects: | |
| Online Access: | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0015.xml |
| _version_ | 1811322643863830528 |
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| author | Emmanuel Amabebe Henry Ogidi Dilly O Anumba |
| author_facet | Emmanuel Amabebe Henry Ogidi Dilly O Anumba |
| author_sort | Emmanuel Amabebe |
| collection | DOAJ |
| description | The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes the myometrial contraction of labour at term or preterm appears to share some common mechanisms with the occurrence, growth, invasion and metastasis of cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are pivotal to the complex extracellular tissue modulation that includes degradation, remodelling and exchange of ECM components, which contribute to homeostasis under normal physiological conditions such as cervical remodelling during pregnancy and puerperium. However, in cancer such as that of the uterine cervix, this extensive network of extracellular tissue modulation is altered leading to disrupted cell–cell and cell–basement membrane adhesion, abnormal tissue growth, neovascularization and metastasis that disrupt homeostasis. Cervical ECM remodelling during pregnancy and puerperium could be a physiological albeit benign neoplasm. In this review, we examined the pathophysiologic differences and similarities in the role of MMPs in cervical remodelling and cervical carcinoma. |
| first_indexed | 2024-04-13T13:38:40Z |
| format | Article |
| id | doaj.art-fc99be96aae745d58db3c4fa3f43faf1 |
| institution | Directory Open Access Journal |
| issn | 2516-5658 |
| language | English |
| last_indexed | 2024-04-13T13:38:40Z |
| publishDate | 2022-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Vascular Biology |
| spelling | doaj.art-fc99be96aae745d58db3c4fa3f43faf12022-12-22T02:44:42ZengBioscientificaVascular Biology2516-56582022-08-0133R177R191https://doi.org/10.1530/RAF-22-0015Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancerEmmanuel Amabebe0Henry Ogidi1Dilly O Anumba2Department of Oncology and Metabolism, University of Sheffield, Sheffield, UKDepartment of Obstetrics and Gynaecology, Glan Clwyd Hospital North Wales, Gwynedd, UKDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UKThe phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes the myometrial contraction of labour at term or preterm appears to share some common mechanisms with the occurrence, growth, invasion and metastasis of cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are pivotal to the complex extracellular tissue modulation that includes degradation, remodelling and exchange of ECM components, which contribute to homeostasis under normal physiological conditions such as cervical remodelling during pregnancy and puerperium. However, in cancer such as that of the uterine cervix, this extensive network of extracellular tissue modulation is altered leading to disrupted cell–cell and cell–basement membrane adhesion, abnormal tissue growth, neovascularization and metastasis that disrupt homeostasis. Cervical ECM remodelling during pregnancy and puerperium could be a physiological albeit benign neoplasm. In this review, we examined the pathophysiologic differences and similarities in the role of MMPs in cervical remodelling and cervical carcinoma.https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0015.xmlcervical remodellingcervical carcinomamatrix metalloproteinasepreterm birthextracellular matrixtissue inhibitors of metalloproteinases |
| spellingShingle | Emmanuel Amabebe Henry Ogidi Dilly O Anumba Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer Vascular Biology cervical remodelling cervical carcinoma matrix metalloproteinase preterm birth extracellular matrix tissue inhibitors of metalloproteinases |
| title | Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer |
| title_full | Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer |
| title_fullStr | Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer |
| title_full_unstemmed | Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer |
| title_short | Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer |
| title_sort | matrix metalloproteinase induced cervical extracellular matrix remodelling in pregnancy and cervical cancer |
| topic | cervical remodelling cervical carcinoma matrix metalloproteinase preterm birth extracellular matrix tissue inhibitors of metalloproteinases |
| url | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0015.xml |
| work_keys_str_mv | AT emmanuelamabebe matrixmetalloproteinaseinducedcervicalextracellularmatrixremodellinginpregnancyandcervicalcancer AT henryogidi matrixmetalloproteinaseinducedcervicalextracellularmatrixremodellinginpregnancyandcervicalcancer AT dillyoanumba matrixmetalloproteinaseinducedcervicalextracellularmatrixremodellinginpregnancyandcervicalcancer |