Extracellular Vesicles and Exosomes: Insights From Exercise Science
The benefits of exercise on health and longevity are well-established, and evidence suggests that these effects are partially driven by a spectrum of bioactive molecules released into circulation during exercise (e.g., exercise factors or ‘exerkines’). Recently, extracellular vesicles (EVs), includi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.604274/full |
| _version_ | 1818412719585361920 |
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| author | Joshua P. Nederveen Geoffrey Warnier Alessia Di Carlo Mats I. Nilsson Mark A. Tarnopolsky Mark A. Tarnopolsky |
| author_facet | Joshua P. Nederveen Geoffrey Warnier Alessia Di Carlo Mats I. Nilsson Mark A. Tarnopolsky Mark A. Tarnopolsky |
| author_sort | Joshua P. Nederveen |
| collection | DOAJ |
| description | The benefits of exercise on health and longevity are well-established, and evidence suggests that these effects are partially driven by a spectrum of bioactive molecules released into circulation during exercise (e.g., exercise factors or ‘exerkines’). Recently, extracellular vesicles (EVs), including microvesicles (MVs) and exosomes or exosome-like vesicles (ELVs), were shown to be secreted concomitantly with exerkines. These EVs have therefore been proposed to act as cargo carriers or ‘mediators’ of intercellular communication. Given these findings, there has been a rapidly growing interest in the role of EVs in the multi-systemic, adaptive response to exercise. This review aims to summarize our current understanding of the effects of exercise on MVs and ELVs, examine their role in the exercise response and long-term adaptations, and highlight the main methodological hurdles related to blood collection, purification, and characterization of ELVs. |
| first_indexed | 2024-12-14T10:51:47Z |
| format | Article |
| id | doaj.art-fc99cf386959424c80b96054f0edbdfe |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T10:51:47Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fc99cf386959424c80b96054f0edbdfe2022-12-21T23:05:11ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-02-011110.3389/fphys.2020.604274604274Extracellular Vesicles and Exosomes: Insights From Exercise ScienceJoshua P. Nederveen0Geoffrey Warnier1Alessia Di Carlo2Mats I. Nilsson3Mark A. Tarnopolsky4Mark A. Tarnopolsky5Department of Pediatrics, McMaster University Medical Centre (MUMC), Hamilton, ON, CanadaInstitut of Neuroscience, UCLouvain, Université catholique de Louvain, Ottignies-Louvain-la-Neuve, BelgiumDepartment of Pediatrics, McMaster University Medical Centre (MUMC), Hamilton, ON, CanadaExerkine Corporation, McMaster University Medical Centre (MUMC), Hamilton, ON, CanadaDepartment of Pediatrics, McMaster University Medical Centre (MUMC), Hamilton, ON, CanadaExerkine Corporation, McMaster University Medical Centre (MUMC), Hamilton, ON, CanadaThe benefits of exercise on health and longevity are well-established, and evidence suggests that these effects are partially driven by a spectrum of bioactive molecules released into circulation during exercise (e.g., exercise factors or ‘exerkines’). Recently, extracellular vesicles (EVs), including microvesicles (MVs) and exosomes or exosome-like vesicles (ELVs), were shown to be secreted concomitantly with exerkines. These EVs have therefore been proposed to act as cargo carriers or ‘mediators’ of intercellular communication. Given these findings, there has been a rapidly growing interest in the role of EVs in the multi-systemic, adaptive response to exercise. This review aims to summarize our current understanding of the effects of exercise on MVs and ELVs, examine their role in the exercise response and long-term adaptations, and highlight the main methodological hurdles related to blood collection, purification, and characterization of ELVs.https://www.frontiersin.org/articles/10.3389/fphys.2020.604274/fullresistance exerciseaerobic exerciseexosomeextracellular vesicleEV isolationsize-exclusion chromatography |
| spellingShingle | Joshua P. Nederveen Geoffrey Warnier Alessia Di Carlo Mats I. Nilsson Mark A. Tarnopolsky Mark A. Tarnopolsky Extracellular Vesicles and Exosomes: Insights From Exercise Science Frontiers in Physiology resistance exercise aerobic exercise exosome extracellular vesicle EV isolation size-exclusion chromatography |
| title | Extracellular Vesicles and Exosomes: Insights From Exercise Science |
| title_full | Extracellular Vesicles and Exosomes: Insights From Exercise Science |
| title_fullStr | Extracellular Vesicles and Exosomes: Insights From Exercise Science |
| title_full_unstemmed | Extracellular Vesicles and Exosomes: Insights From Exercise Science |
| title_short | Extracellular Vesicles and Exosomes: Insights From Exercise Science |
| title_sort | extracellular vesicles and exosomes insights from exercise science |
| topic | resistance exercise aerobic exercise exosome extracellular vesicle EV isolation size-exclusion chromatography |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2020.604274/full |
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