Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus
BACKGROUND AND OBJECTIVE: Copper nanoparticles are being extensively used in medical sciences, food supplements and industrial fields. However, their potential toxic effects on human health and the environment remain undetermined. The purpose of this study was to evaluate the toxic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2015-07-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/browse.php?a_code=A-10-1571-1&slc_lang=en&sid=1 |
| _version_ | 1811253344671367168 |
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| author | B Seyedalipour N Barimani AA Dehpour Jooybari S M Hosseini M Oshrieh |
| author_facet | B Seyedalipour N Barimani AA Dehpour Jooybari S M Hosseini M Oshrieh |
| author_sort | B Seyedalipour |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: Copper nanoparticles are being extensively used in medical sciences, food supplements and industrial fields. However, their potential toxic effects on human health and the environment remain undetermined. The purpose of this study was to evaluate the toxic effects of copper oxide nanoparticles on kidney and heart tissues of mice.
METHODS: In this experimental study, 42 adult female mice, weighing 30±3 g, were randomly divided into control, sham and four experimental groups. The mice in the experimental groups intraperitoneally received copper oxide nanoparticles with doses of 300, 400, 500 and 600 mg/kg. After autopsy, the hearts and kidneys of mice were separated and weighed. For histopathological examinations, heart and kidney tissues were stained with hematoxylin and eosin.
FINDINGS: Kidney weight in control and sham groups, compared to experimental groups receiving nanoparticle doses of 300, 400, 500 and 600 mg/kg, reduced to 21±0.02, 19±0.02, 20±0.02 and 22±0.01 g, respectively, while no significant changes were observed in the heart weight. Histopathological examination of kidney and heart after the intraperitoneal injection of copper oxide nanoparticles showed signs of cytotoxicity including congestion, necrosis and inflammatory cell infiltration, compared to the control group.
CONCLUSION: The findings of this study showed that copper oxide nanoparticles cause damage to the kidney and heart in a dose-dependent way |
| first_indexed | 2024-04-12T16:49:29Z |
| format | Article |
| id | doaj.art-fc9a519e65c7414c98a486f52c598218 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-04-12T16:49:29Z |
| publishDate | 2015-07-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-fc9a519e65c7414c98a486f52c5982182022-12-22T03:24:28ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702015-07-011774450Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculusB Seyedalipour0N Barimani1AA Dehpour Jooybari2S M Hosseini3M Oshrieh4 BACKGROUND AND OBJECTIVE: Copper nanoparticles are being extensively used in medical sciences, food supplements and industrial fields. However, their potential toxic effects on human health and the environment remain undetermined. The purpose of this study was to evaluate the toxic effects of copper oxide nanoparticles on kidney and heart tissues of mice. METHODS: In this experimental study, 42 adult female mice, weighing 30±3 g, were randomly divided into control, sham and four experimental groups. The mice in the experimental groups intraperitoneally received copper oxide nanoparticles with doses of 300, 400, 500 and 600 mg/kg. After autopsy, the hearts and kidneys of mice were separated and weighed. For histopathological examinations, heart and kidney tissues were stained with hematoxylin and eosin. FINDINGS: Kidney weight in control and sham groups, compared to experimental groups receiving nanoparticle doses of 300, 400, 500 and 600 mg/kg, reduced to 21±0.02, 19±0.02, 20±0.02 and 22±0.01 g, respectively, while no significant changes were observed in the heart weight. Histopathological examination of kidney and heart after the intraperitoneal injection of copper oxide nanoparticles showed signs of cytotoxicity including congestion, necrosis and inflammatory cell infiltration, compared to the control group. CONCLUSION: The findings of this study showed that copper oxide nanoparticles cause damage to the kidney and heart in a dose-dependent wayhttp://jbums.org/browse.php?a_code=A-10-1571-1&slc_lang=en&sid=1Copper Oxide Nanoparticles Cytotoxicity Mus musculus Histopathology Necrosis Inflammatory Cell Infiltration. |
| spellingShingle | B Seyedalipour N Barimani AA Dehpour Jooybari S M Hosseini M Oshrieh Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul Copper Oxide Nanoparticles Cytotoxicity Mus musculus Histopathology Necrosis Inflammatory Cell Infiltration. |
| title | Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus |
| title_full | Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus |
| title_fullStr | Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus |
| title_full_unstemmed | Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus |
| title_short | Histopathological Evaluation of Kidney and Heart Tissues after Exposure to Copper Oxide Nanoparticles in Mus musculus |
| title_sort | histopathological evaluation of kidney and heart tissues after exposure to copper oxide nanoparticles in mus musculus |
| topic | Copper Oxide Nanoparticles Cytotoxicity Mus musculus Histopathology Necrosis Inflammatory Cell Infiltration. |
| url | http://jbums.org/browse.php?a_code=A-10-1571-1&slc_lang=en&sid=1 |
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