Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models
Dysfunctional blood vessels are implicated in various diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. Several studies have attempted to prevent and treat vascular diseases and understand interactions between these diseases and blood vessels across different organ...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2023-01-01
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| Series: | Cyborg and Bionic Systems |
| Online Access: | https://spj.science.org/doi/10.34133/cbsystems.0043 |
| _version_ | 1827888166627966976 |
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| author | Seon-Jin Kim Min-Gyun Kim Jangho Kim Jessie S. Jeon Jinsoo Park Hee-Gyeong Yi |
| author_facet | Seon-Jin Kim Min-Gyun Kim Jangho Kim Jessie S. Jeon Jinsoo Park Hee-Gyeong Yi |
| author_sort | Seon-Jin Kim |
| collection | DOAJ |
| description | Dysfunctional blood vessels are implicated in various diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. Several studies have attempted to prevent and treat vascular diseases and understand interactions between these diseases and blood vessels across different organs and tissues. Initial studies were conducted using 2-dimensional (2D) in vitro and animal models. However, these models have difficulties in mimicking the 3D microenvironment in human, simulating kinetics related to cell activities, and replicating human pathophysiology; in addition, 3D models involve remarkably high costs. Thus, in vitro bioengineered models (BMs) have recently gained attention. BMs created through biofabrication based on tissue engineering and regenerative medicine are breakthrough models that can overcome limitations of 2D and animal models. They can also simulate the natural microenvironment in a patient- and target-specific manner. In this review, we will introduce 3D bioprinting methods for fabricating bioengineered blood vessel models, which can serve as the basis for treating and preventing various vascular diseases. Additionally, we will describe possible advancements from tubular to vascular models. Last, we will discuss specific applications, limitations, and future perspectives of fabricated BMs. |
| first_indexed | 2024-03-12T20:29:52Z |
| format | Article |
| id | doaj.art-fc9b3562a0ec4c949de539d23bd415d2 |
| institution | Directory Open Access Journal |
| issn | 2692-7632 |
| language | English |
| last_indexed | 2024-03-12T20:29:52Z |
| publishDate | 2023-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Cyborg and Bionic Systems |
| spelling | doaj.art-fc9b3562a0ec4c949de539d23bd415d22023-08-02T00:13:47ZengAmerican Association for the Advancement of Science (AAAS)Cyborg and Bionic Systems2692-76322023-01-01410.34133/cbsystems.0043Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel ModelsSeon-Jin Kim0Min-Gyun Kim1Jangho Kim2Jessie S. Jeon3Jinsoo Park4Hee-Gyeong Yi5Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea.Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea.Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea.Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.Department of Mechanical Engineering, Chonnam National University, Republic of Korea.Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea.Dysfunctional blood vessels are implicated in various diseases, including cardiovascular diseases, neurodegenerative diseases, and cancer. Several studies have attempted to prevent and treat vascular diseases and understand interactions between these diseases and blood vessels across different organs and tissues. Initial studies were conducted using 2-dimensional (2D) in vitro and animal models. However, these models have difficulties in mimicking the 3D microenvironment in human, simulating kinetics related to cell activities, and replicating human pathophysiology; in addition, 3D models involve remarkably high costs. Thus, in vitro bioengineered models (BMs) have recently gained attention. BMs created through biofabrication based on tissue engineering and regenerative medicine are breakthrough models that can overcome limitations of 2D and animal models. They can also simulate the natural microenvironment in a patient- and target-specific manner. In this review, we will introduce 3D bioprinting methods for fabricating bioengineered blood vessel models, which can serve as the basis for treating and preventing various vascular diseases. Additionally, we will describe possible advancements from tubular to vascular models. Last, we will discuss specific applications, limitations, and future perspectives of fabricated BMs.https://spj.science.org/doi/10.34133/cbsystems.0043 |
| spellingShingle | Seon-Jin Kim Min-Gyun Kim Jangho Kim Jessie S. Jeon Jinsoo Park Hee-Gyeong Yi Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models Cyborg and Bionic Systems |
| title | Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models |
| title_full | Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models |
| title_fullStr | Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models |
| title_full_unstemmed | Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models |
| title_short | Bioprinting Methods for Fabricating In Vitro Tubular Blood Vessel Models |
| title_sort | bioprinting methods for fabricating in vitro tubular blood vessel models |
| url | https://spj.science.org/doi/10.34133/cbsystems.0043 |
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