RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex
Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.
| Auteurs principaux: | , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Nature Portfolio
2021-05-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-021-22770-4 |
| _version_ | 1828902535949189120 |
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| author | Timothy S. Catlett Massimo M. Onesto Alec J. McCann Sarah K. Rempel Jennifer Glass David N. Franz Timothy M. Gómez |
| author_facet | Timothy S. Catlett Massimo M. Onesto Alec J. McCann Sarah K. Rempel Jennifer Glass David N. Franz Timothy M. Gómez |
| author_sort | Timothy S. Catlett |
| collection | DOAJ |
| description | Patients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance. |
| first_indexed | 2024-12-13T16:18:22Z |
| format | Article |
| id | doaj.art-fc9b5914dcfa4ad4b2da1ea8ef8bcc7c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:18:22Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fc9b5914dcfa4ad4b2da1ea8ef8bcc7c2022-12-21T23:38:48ZengNature PortfolioNature Communications2041-17232021-05-0112111510.1038/s41467-021-22770-4RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complexTimothy S. Catlett0Massimo M. Onesto1Alec J. McCann2Sarah K. Rempel3Jennifer Glass4David N. Franz5Timothy M. Gómez6Department of Neuroscience, University of Wisconsin School of Medicine and Public HealthDepartment of Neuroscience, University of Wisconsin School of Medicine and Public HealthDepartment of Neuroscience, University of Wisconsin School of Medicine and Public HealthDepartment of Neuroscience, University of Wisconsin School of Medicine and Public HealthDepartment of Pediatrics, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, Cincinnati Children’s Hospital Medical CenterDepartment of Neuroscience, University of Wisconsin School of Medicine and Public HealthPatients with Tuberous Sclerosis Complex (TSC) show aberrant wiring of neuronal connections. Here, the authors generate iPSC-derived neurons from patients with TSC. TSC2 +/− neurons show impaired mTOR-independent RhoA signaling-mediated axon guidance.https://doi.org/10.1038/s41467-021-22770-4 |
| spellingShingle | Timothy S. Catlett Massimo M. Onesto Alec J. McCann Sarah K. Rempel Jennifer Glass David N. Franz Timothy M. Gómez RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex Nature Communications |
| title | RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex |
| title_full | RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex |
| title_fullStr | RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex |
| title_full_unstemmed | RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex |
| title_short | RHOA signaling defects result in impaired axon guidance in iPSC-derived neurons from patients with tuberous sclerosis complex |
| title_sort | rhoa signaling defects result in impaired axon guidance in ipsc derived neurons from patients with tuberous sclerosis complex |
| url | https://doi.org/10.1038/s41467-021-22770-4 |
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