Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process
Abstract Objectives Patient’s health-related quality of life (HRQoL) is an important outcome measure that is considered by many payers and health technology assessment (HTA) bodies in the evaluation of treatments. We aimed to identify opportunities for HRQoL to be further incorporated into the asses...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Health Research Policy and Systems |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12961-023-01081-8 |
| _version_ | 1797376740330307584 |
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| author | Hugo Larose Myrto Lee Jens Grueger Amélie Anota Nicolas Naïditch Bruno Falissard Mario Di Palma Olivier Chassany Laura Khalfallah-Neelz Sarah Palazuelos-Muñoz Aymeric Tetafort |
| author_facet | Hugo Larose Myrto Lee Jens Grueger Amélie Anota Nicolas Naïditch Bruno Falissard Mario Di Palma Olivier Chassany Laura Khalfallah-Neelz Sarah Palazuelos-Muñoz Aymeric Tetafort |
| author_sort | Hugo Larose |
| collection | DOAJ |
| description | Abstract Objectives Patient’s health-related quality of life (HRQoL) is an important outcome measure that is considered by many payers and health technology assessment (HTA) bodies in the evaluation of treatments. We aimed to identify opportunities for HRQoL to be further incorporated into the assessment of the French HTA by comparing three health systems. We put forward recommendations that could bring further innovations to French patients. Methods We reviewed methodologies by the French, German and British HTA, and conducted a systematic review of all French (n = 312) and German (n = 175) HTA appraisals from 01 January 2019 to 31 December 2021. We also setup an advisory board of 11 ex-HTA leaders, payers, methodologists, healthcare providers and patient advocates, from France, Britain and Germany, to discuss opportunities to improve acceptance and adoption of HRQoL evidence in France. Results Our systematic review of HTA appraisals showed a higher HRQoL data rejection rate in France: in > 75% of cases the HRQoL evidence submitted was not accepted for the assessment (usually for methodological reasons, for example, data being considered exploratory; 16–75% of the appraisals mentioned HRQoL evidence, varying by therapeutic area). Overall, we found the French HTA to be more restrictive in its approach than IQWiG. Conclusions Based on these findings we articulate collaborative proposals for industry and the HAS to improve acceptance of HRQoL evidence and create a positive feedback loop between HAS and industry along four dimensions (1) patient perception, (2) testing hierarchy, (3) trial design and (4) data collection. |
| first_indexed | 2024-03-08T19:43:04Z |
| format | Article |
| id | doaj.art-fc9bb172dbd546d6bf1e7b04e9e31049 |
| institution | Directory Open Access Journal |
| issn | 1478-4505 |
| language | English |
| last_indexed | 2024-03-08T19:43:04Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Health Research Policy and Systems |
| spelling | doaj.art-fc9bb172dbd546d6bf1e7b04e9e310492023-12-24T12:32:29ZengBMCHealth Research Policy and Systems1478-45052023-12-0121111210.1186/s12961-023-01081-8Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment processHugo Larose0Myrto Lee1Jens Grueger2Amélie Anota3Nicolas Naïditch4Bruno Falissard5Mario Di Palma6Olivier Chassany7Laura Khalfallah-Neelz8Sarah Palazuelos-Muñoz9Aymeric Tetafort10The Boston Consulting GroupThe Boston Consulting GroupUniversity of WashingtonDepartment of Clinical Research and Innovation and Department of Human and Social Sciences, Centre Léon BérardFrench Federation of DiabeticsCESP, Université Paris-Saclay, APHPGustave Roussy Cancer Center, Paris-Saclay UniversityHealth Economics Clinical Trial Unit (URC-ECO), Hôpital Hotel-Dieu, AP-HPAstraZenecaAstraZenecaAstraZenecaAbstract Objectives Patient’s health-related quality of life (HRQoL) is an important outcome measure that is considered by many payers and health technology assessment (HTA) bodies in the evaluation of treatments. We aimed to identify opportunities for HRQoL to be further incorporated into the assessment of the French HTA by comparing three health systems. We put forward recommendations that could bring further innovations to French patients. Methods We reviewed methodologies by the French, German and British HTA, and conducted a systematic review of all French (n = 312) and German (n = 175) HTA appraisals from 01 January 2019 to 31 December 2021. We also setup an advisory board of 11 ex-HTA leaders, payers, methodologists, healthcare providers and patient advocates, from France, Britain and Germany, to discuss opportunities to improve acceptance and adoption of HRQoL evidence in France. Results Our systematic review of HTA appraisals showed a higher HRQoL data rejection rate in France: in > 75% of cases the HRQoL evidence submitted was not accepted for the assessment (usually for methodological reasons, for example, data being considered exploratory; 16–75% of the appraisals mentioned HRQoL evidence, varying by therapeutic area). Overall, we found the French HTA to be more restrictive in its approach than IQWiG. Conclusions Based on these findings we articulate collaborative proposals for industry and the HAS to improve acceptance of HRQoL evidence and create a positive feedback loop between HAS and industry along four dimensions (1) patient perception, (2) testing hierarchy, (3) trial design and (4) data collection.https://doi.org/10.1186/s12961-023-01081-8Health-related quality of life (HRQoL)Health technology assessment (HTA)Haute Authorite de la Sante (HAS)EUnetHTAPatient perceptionTesting hierarchy |
| spellingShingle | Hugo Larose Myrto Lee Jens Grueger Amélie Anota Nicolas Naïditch Bruno Falissard Mario Di Palma Olivier Chassany Laura Khalfallah-Neelz Sarah Palazuelos-Muñoz Aymeric Tetafort Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process Health Research Policy and Systems Health-related quality of life (HRQoL) Health technology assessment (HTA) Haute Authorite de la Sante (HAS) EUnetHTA Patient perception Testing hierarchy |
| title | Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process |
| title_full | Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process |
| title_fullStr | Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process |
| title_full_unstemmed | Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process |
| title_short | Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process |
| title_sort | opportunities to improve the adoption of health related quality of life evidence as part of the french health technology assessment process |
| topic | Health-related quality of life (HRQoL) Health technology assessment (HTA) Haute Authorite de la Sante (HAS) EUnetHTA Patient perception Testing hierarchy |
| url | https://doi.org/10.1186/s12961-023-01081-8 |
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