Evaluation of the Role of Diffusion Tensor Imaging in Grading of Glial Tumors based on Relative Anisotropy
Background: The most common primary tumors of the brain are gliomas. Despite improvements in treatment strategy, the prognosis for patients with high-grade gliomas has stayed poor, while it is relatively good for low-grade gliomas. The main and gold standard way for grading glial tumor is biopsy. Ac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2016-01-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/5347 |
| Summary: | Background: The most common primary tumors of the brain are gliomas. Despite improvements in treatment strategy, the prognosis for patients with high-grade gliomas has stayed poor, while it is relatively good for low-grade gliomas. The main and gold standard way for grading glial tumor is biopsy. Accurate assessment of tumor grade is vital for the determination of best treatment plan. The purpose of this study was to evaluate the role of diffusion tensor imaging (as a noninvasive method) using relative anisotropy (RA) in glial tumor grading.
Methods: A total of 20 histologically confirmed gliomas patients were scanned using a 1.5-Tesla magnetic resonance scanner. We described two regions of interest (ROIs), white matter adjacent to the tumor and the homologous fiber tracts to first ROI in the contralateral hemisphere.
Findings: The relative anisotropy values and ratio of the low-grade gliomas tended to be higher than those of the high-grade gliomas in the peritumoral fibers (P = 0.008, for RAt and P = 0.039 for RAt/n).
Conclusion: Our findings prove that the relative anisotropy was different between low- and high-grade gliomas, which may be helpful in grading. |
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| ISSN: | 1027-7595 1735-854X |