The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease
Abstract Noncommunicable chronic diseases (NCCDs) are the leading causes of morbidity and mortality globally. The mismatch between present day diets and ancestral genome is suggested to contribute to the NCCDs burden, which is promoted by traditional risk factors like unhealthy diets, physical inact...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-11-01
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| Series: | Global Challenges |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/gch2.201700043 |
| _version_ | 1797743758617346048 |
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| author | Mustapha U. Imam Maznah Ismail |
| author_facet | Mustapha U. Imam Maznah Ismail |
| author_sort | Mustapha U. Imam |
| collection | DOAJ |
| description | Abstract Noncommunicable chronic diseases (NCCDs) are the leading causes of morbidity and mortality globally. The mismatch between present day diets and ancestral genome is suggested to contribute to the NCCDs burden, which is promoted by traditional risk factors like unhealthy diets, physical inactivity, alcohol and tobacco. However, epigenetic evidence now suggests that cumulatively inherited epigenetic modifications may have made humans more prone to the effects of present day lifestyle factors. Perinatal starvation was widespread in the 19th century. This together with more recent events like increasing consumption of western and low fiber diets, smoking, harmful use of alcohol, physical inactivity, and environmental pollutants may have programed the human epigenome for higher NCCDs risk. In this review, on the basis of available epigenetic data it is hypothesized that transgenerational effects of lifestyle factors may be contributing to the current global burden of NCCDs. Thus, there is a need to reconsider prevention strategies so that the subsequent generations will not have to pay for our sins and those of our ancestors. |
| first_indexed | 2024-03-12T15:00:02Z |
| format | Article |
| id | doaj.art-fc9dbc39e5134f44997ce69759061218 |
| institution | Directory Open Access Journal |
| issn | 2056-6646 |
| language | English |
| last_indexed | 2024-03-12T15:00:02Z |
| publishDate | 2017-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Global Challenges |
| spelling | doaj.art-fc9dbc39e5134f44997ce697590612182023-08-14T09:40:26ZengWileyGlobal Challenges2056-66462017-11-0118n/an/a10.1002/gch2.201700043The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic DiseaseMustapha U. Imam0Maznah Ismail1Precision Nutrition Innovation Institute College of Public Health Zhengzhou University Zhengzhou 450001 ChinaLaboratory of Molecular Biomedicine Institute of Bioscience Universiti Putra Malaysia Serdang Selangor 43400 MalaysiaAbstract Noncommunicable chronic diseases (NCCDs) are the leading causes of morbidity and mortality globally. The mismatch between present day diets and ancestral genome is suggested to contribute to the NCCDs burden, which is promoted by traditional risk factors like unhealthy diets, physical inactivity, alcohol and tobacco. However, epigenetic evidence now suggests that cumulatively inherited epigenetic modifications may have made humans more prone to the effects of present day lifestyle factors. Perinatal starvation was widespread in the 19th century. This together with more recent events like increasing consumption of western and low fiber diets, smoking, harmful use of alcohol, physical inactivity, and environmental pollutants may have programed the human epigenome for higher NCCDs risk. In this review, on the basis of available epigenetic data it is hypothesized that transgenerational effects of lifestyle factors may be contributing to the current global burden of NCCDs. Thus, there is a need to reconsider prevention strategies so that the subsequent generations will not have to pay for our sins and those of our ancestors.https://doi.org/10.1002/gch2.201700043cancercardiovascular diseasesepigeneticsglobal burdenstype 2 diabetes |
| spellingShingle | Mustapha U. Imam Maznah Ismail The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease Global Challenges cancer cardiovascular diseases epigenetics global burdens type 2 diabetes |
| title | The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease |
| title_full | The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease |
| title_fullStr | The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease |
| title_full_unstemmed | The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease |
| title_short | The Impact of Traditional Food and Lifestyle Behavior on Epigenetic Burden of Chronic Disease |
| title_sort | impact of traditional food and lifestyle behavior on epigenetic burden of chronic disease |
| topic | cancer cardiovascular diseases epigenetics global burdens type 2 diabetes |
| url | https://doi.org/10.1002/gch2.201700043 |
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