Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

Summary: The antidiabetic potential of glucagon receptor antagonism presents an opportunity for use in an insulin-centric clinical environment. To investigate the metabolic effects of glucagon receptor antagonism in type 2 diabetes, we treated Leprdb/db and Lepob/ob mice with REMD 2.59, a human mono...

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Bibliographic Details
Main Authors: Ankit X. Sharma, Ezekiel B. Quittner-Strom, Young Lee, Joshua A. Johnson, Sarah A. Martin, Xinxin Yu, Jianping Li, John Lu, Zheqing Cai, Shiuhwei Chen, May-yun Wang, Yiyi Zhang, Mackenzie J. Pearson, Andie C. Dorn, Jeffrey G. McDonald, Ruth Gordillo, Hai Yan, Dung Thai, Zhao V. Wang, Roger H. Unger, William L. Holland
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
ceramide
lipotoxicity
adiponectin
sphingolipid
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301141

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