Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2

Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2

Capsaicin has been reported to preferentially inhibit the activity of tumor-associated NADH oxidase (tNOX), which belongs to a family of growth-related plasma membrane hydroquinone oxidases in cancer/transformed cells. The inhibitory effect of capsaicin on tNOX is associated with cell growth attenua...

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Bibliographic Details
Main Authors: Hung Yen Chen, Yi Hui Lee, Huei Yu Chen, Chia An Yeh, Pin Ju Chueh, Yi-Mei J. Lin
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
POU3F2-binding motif
tumor-associated NADH oxidase (tNOX)
transcriptional regulation
cancer
Online Access:http://www.mdpi.com/1420-3049/21/6/733

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