Desmoglein 3: A Help or a Hindrance in Cancer Progression?
Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-01-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/7/1/266 |
| _version_ | 1797710742264217600 |
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| author | Louise Brown Hong Wan |
| author_facet | Louise Brown Hong Wan |
| author_sort | Louise Brown |
| collection | DOAJ |
| description | Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity. Like adherens junctions, desmosomes function as tumour suppressors and are down regulated in the process of epithelial-mesenchymal transition and in tumour cell invasion and metastasis. However, recently several studies have shown that various desmosomal components, including desmoglein 3, are up-regulated in cancer with increased levels of expression correlating with the clinical stage of malignancy, implicating their potentiality to serve as a diagnostic and prognostic marker. Furthermore, in vitro studies have demonstrated that overexpression of desmoglein 3 in cancer cell lines activates several signal pathways that have an impact on cell morphology, adhesion and locomotion. These additional signalling roles of desmoglein 3 may not be associated to its adhesive function in desmosomes but rather function outside of the junctions, acting as a key regulator in the control of actin based cellular processes. This review will discuss recent advances which support the role of desmoglein 3 in cancer progression. |
| first_indexed | 2024-03-12T06:56:39Z |
| format | Article |
| id | doaj.art-fc9ef6ccee8d4874b387aa380c95cc01 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:56:39Z |
| publishDate | 2015-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fc9ef6ccee8d4874b387aa380c95cc012023-09-03T00:04:24ZengMDPI AGCancers2072-66942015-01-017126628610.3390/cancers7010266cancers7010266Desmoglein 3: A Help or a Hindrance in Cancer Progression?Louise Brown0Hong Wan1Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Center for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Blizard Building, London E1 2AT, UKQueen Mary University of London, Barts and the London School of Medicine and Dentistry, Center for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Blizard Building, London E1 2AT, UKDesmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are essential in the maintenance of tissue architecture and structural integrity. Like adherens junctions, desmosomes function as tumour suppressors and are down regulated in the process of epithelial-mesenchymal transition and in tumour cell invasion and metastasis. However, recently several studies have shown that various desmosomal components, including desmoglein 3, are up-regulated in cancer with increased levels of expression correlating with the clinical stage of malignancy, implicating their potentiality to serve as a diagnostic and prognostic marker. Furthermore, in vitro studies have demonstrated that overexpression of desmoglein 3 in cancer cell lines activates several signal pathways that have an impact on cell morphology, adhesion and locomotion. These additional signalling roles of desmoglein 3 may not be associated to its adhesive function in desmosomes but rather function outside of the junctions, acting as a key regulator in the control of actin based cellular processes. This review will discuss recent advances which support the role of desmoglein 3 in cancer progression.http://www.mdpi.com/2072-6694/7/1/266desmoglein 3cell signallingdesmosomescell-cell adhesionsquamous cell carcinomacancer biomarkercancer progressioncancer suppressionmetastasis |
| spellingShingle | Louise Brown Hong Wan Desmoglein 3: A Help or a Hindrance in Cancer Progression? Cancers desmoglein 3 cell signalling desmosomes cell-cell adhesion squamous cell carcinoma cancer biomarker cancer progression cancer suppression metastasis |
| title | Desmoglein 3: A Help or a Hindrance in Cancer Progression? |
| title_full | Desmoglein 3: A Help or a Hindrance in Cancer Progression? |
| title_fullStr | Desmoglein 3: A Help or a Hindrance in Cancer Progression? |
| title_full_unstemmed | Desmoglein 3: A Help or a Hindrance in Cancer Progression? |
| title_short | Desmoglein 3: A Help or a Hindrance in Cancer Progression? |
| title_sort | desmoglein 3 a help or a hindrance in cancer progression |
| topic | desmoglein 3 cell signalling desmosomes cell-cell adhesion squamous cell carcinoma cancer biomarker cancer progression cancer suppression metastasis |
| url | http://www.mdpi.com/2072-6694/7/1/266 |
| work_keys_str_mv | AT louisebrown desmoglein3ahelporahindranceincancerprogression AT hongwan desmoglein3ahelporahindranceincancerprogression |