The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice
A convincing number of epidemiological studies have reported on the exposure to and consequences of organophosphorus compounds (OPCs) in pregnant women. However, there is still a knowledge gap and paucity of systematic literature from animal studies. This study was undertaken with the hypot...
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2015-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500045N.pdf |
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| author | Nurulain Syed M. Shafiullah Mohamed Sharma Charu Ali Mahmoud A. Ojha Shreesh |
| author_facet | Nurulain Syed M. Shafiullah Mohamed Sharma Charu Ali Mahmoud A. Ojha Shreesh |
| author_sort | Nurulain Syed M. |
| collection | DOAJ |
| description | A convincing number of epidemiological studies have reported on the exposure
to and consequences of organophosphorus compounds (OPCs) in pregnant women.
However, there is still a knowledge gap and paucity of systematic literature
from animal studies. This study was undertaken with the hypothesis that
short-duration sublethal exposure to OPCs can produce maternal and fetal
lethal effects as chronic exposure. This study examineses the teratogenicity
and embryotoxicity of paraoxon (POX) in mice at a dose that is non-lethal to
non-pregnant mothers. Pregnant mice were injected intraperitoneally (i.p.)
with paraoxon (50 nmol/mouse) on the 4th and 5th days of gestation, and the
effect of the treatment was assessed on day 18 of gestation. This dose was
fatal to pregnant mice in 21% of instances as compared to non-pregnant
animals in which 0% mortality was detected, even after daily injection of a
similar dose for five days. Significant inhibition of red blood cell
acetylcholinesterase (RBC-AChE) was observed in pregnant mice as compared to
non-pregnant ones; however, no apparent neuronal effect was detected. Of note
were fetal weight decrement, pregnancy termination, intrauterine growth
retardation and maternal death. We concluded that exposure to even a
non-toxic dose might be critical for pregnant mothers, the pregnancy as well
as fetuses. In addition, even exposure of short duration can be detrimental
and capable of producing profound and fatal effects. |
| first_indexed | 2024-12-18T15:18:01Z |
| format | Article |
| id | doaj.art-fc9f5e5d6034447ca26df4cb4b112092 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-18T15:18:01Z |
| publishDate | 2015-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-fc9f5e5d6034447ca26df4cb4b1120922022-12-21T21:03:29ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392015-01-0167386186710.2298/ABS141114045N0354-46641500045NThe effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in miceNurulain Syed M.0Shafiullah Mohamed1Sharma Charu2Ali Mahmoud A.3Ojha Shreesh4United Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, Al Ain, Abu Dhabi, UAEUnited Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, Al Ain, Abu Dhabi, UAEUnited Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Internal Medicine, Al Ain, Abu Dhabi, UAEUnited Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, Al Ain, Abu Dhabi, UAEUnited Arab Emirates University, Faculty of Medicine and Health Sciences, Department of Pharmacology and Therapeutics, Al Ain, Abu Dhabi, UAEA convincing number of epidemiological studies have reported on the exposure to and consequences of organophosphorus compounds (OPCs) in pregnant women. However, there is still a knowledge gap and paucity of systematic literature from animal studies. This study was undertaken with the hypothesis that short-duration sublethal exposure to OPCs can produce maternal and fetal lethal effects as chronic exposure. This study examineses the teratogenicity and embryotoxicity of paraoxon (POX) in mice at a dose that is non-lethal to non-pregnant mothers. Pregnant mice were injected intraperitoneally (i.p.) with paraoxon (50 nmol/mouse) on the 4th and 5th days of gestation, and the effect of the treatment was assessed on day 18 of gestation. This dose was fatal to pregnant mice in 21% of instances as compared to non-pregnant animals in which 0% mortality was detected, even after daily injection of a similar dose for five days. Significant inhibition of red blood cell acetylcholinesterase (RBC-AChE) was observed in pregnant mice as compared to non-pregnant ones; however, no apparent neuronal effect was detected. Of note were fetal weight decrement, pregnancy termination, intrauterine growth retardation and maternal death. We concluded that exposure to even a non-toxic dose might be critical for pregnant mothers, the pregnancy as well as fetuses. In addition, even exposure of short duration can be detrimental and capable of producing profound and fatal effects.http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500045N.pdfIntrauterine growth restriction (IUGR)gestation day (GD)RBC-AChEorganophosphorous compound (OPC)paraoxon (POX) |
| spellingShingle | Nurulain Syed M. Shafiullah Mohamed Sharma Charu Ali Mahmoud A. Ojha Shreesh The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice Archives of Biological Sciences Intrauterine growth restriction (IUGR) gestation day (GD) RBC-AChE organophosphorous compound (OPC) paraoxon (POX) |
| title | The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice |
| title_full | The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice |
| title_fullStr | The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice |
| title_full_unstemmed | The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice |
| title_short | The effect of sublethal short-duration exposure of paraoxon on pregnancy and fetuses in mice |
| title_sort | effect of sublethal short duration exposure of paraoxon on pregnancy and fetuses in mice |
| topic | Intrauterine growth restriction (IUGR) gestation day (GD) RBC-AChE organophosphorous compound (OPC) paraoxon (POX) |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2015/0354-46641500045N.pdf |
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