Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave
Abstract Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46800-x |
| _version_ | 1827377358693203968 |
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| author | Yun Shan Goh Siew-Wai Fong Matthew Zirui Tay Angeline Rouers Zi Wei Chang Jean-Marc Chavatte Pei Xiang Hor Chiew Yee Loh Yuling Huang Yong Jie Tan Bei Wang Eve Zi Xian Ngoh Siti Nazihah Mohd Salleh Raphael Tze Chuen Lee Georgina Lim NCID Study Group COVID-Study Group Sebastian Maurer-Stroh Cheng-I Wang Yee‐Sin Leo Raymond T. P. Lin Meng Chon Lam David C. Lye Barnaby Edward Young Lisa F. P. Ng Laurent Renia |
| author_facet | Yun Shan Goh Siew-Wai Fong Matthew Zirui Tay Angeline Rouers Zi Wei Chang Jean-Marc Chavatte Pei Xiang Hor Chiew Yee Loh Yuling Huang Yong Jie Tan Bei Wang Eve Zi Xian Ngoh Siti Nazihah Mohd Salleh Raphael Tze Chuen Lee Georgina Lim NCID Study Group COVID-Study Group Sebastian Maurer-Stroh Cheng-I Wang Yee‐Sin Leo Raymond T. P. Lin Meng Chon Lam David C. Lye Barnaby Edward Young Lisa F. P. Ng Laurent Renia |
| author_sort | Yun Shan Goh |
| collection | DOAJ |
| description | Abstract Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-risk groups. In this study, we recruited 158 mRNA-vaccinated individuals during the Delta wave of SARS-CoV-2 infections in Singapore and examined the antibody profiles of infected individuals. We found that, despite high exposure due to communal living conditions in proximity, 4% of individuals (6/158) had PCR-confirmed infections and 96% (152/158) remained uninfected. Time-course analysis of the antibody profile at the start and the end of quarantine period showed Delta-specific boosting of anti-spike antibody response in 57% of the uninfected individuals (86/152). In the remaining 43% of the uninfected individuals (66/152) with no Delta-specific antibody boost, we found a higher Delta-specific antibody response at the start of quarantine period, which correlated with higher Delta pseudovirus neutralizing capacity. Our findings indicate that a higher basal variant-specific antibody response in the mRNA-vaccinated individuals contributes to better protection against infections by the new emerging SARS-CoV-2 variants. |
| first_indexed | 2024-03-08T12:37:59Z |
| format | Article |
| id | doaj.art-fca10ae838194a84adcc6ba332be6ca8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T12:37:59Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fca10ae838194a84adcc6ba332be6ca82024-01-21T12:23:01ZengNature PortfolioScientific Reports2045-23222023-11-011311710.1038/s41598-023-46800-xHigher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta waveYun Shan Goh0Siew-Wai Fong1Matthew Zirui Tay2Angeline Rouers3Zi Wei Chang4Jean-Marc Chavatte5Pei Xiang Hor6Chiew Yee Loh7Yuling Huang8Yong Jie Tan9Bei Wang10Eve Zi Xian Ngoh11Siti Nazihah Mohd Salleh12Raphael Tze Chuen Lee13Georgina Lim14NCID Study Group15COVID-Study Group16Sebastian Maurer-Stroh17Cheng-I Wang18Yee‐Sin Leo19Raymond T. P. Lin20Meng Chon Lam21David C. Lye22Barnaby Edward Young23Lisa F. P. Ng24Laurent Renia25A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)National Public Health Laboratory, National Centre for Infectious DiseasesA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)Singapore Immunology Network, A*STARSingapore Immunology Network, A*STARSingapore Immunology Network, A*STARBioinformatics Institute, A*STARMinistry of Health (MOH)National Centre for Infectious Diseases (NCID)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)Singapore Immunology Network, A*STARNational Centre for Infectious Diseases (NCID)National Public Health Laboratory, National Centre for Infectious DiseasesMinistry of Health (MOH)National Centre for Infectious Diseases (NCID)National Centre for Infectious Diseases (NCID)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR)Abstract Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-risk groups. In this study, we recruited 158 mRNA-vaccinated individuals during the Delta wave of SARS-CoV-2 infections in Singapore and examined the antibody profiles of infected individuals. We found that, despite high exposure due to communal living conditions in proximity, 4% of individuals (6/158) had PCR-confirmed infections and 96% (152/158) remained uninfected. Time-course analysis of the antibody profile at the start and the end of quarantine period showed Delta-specific boosting of anti-spike antibody response in 57% of the uninfected individuals (86/152). In the remaining 43% of the uninfected individuals (66/152) with no Delta-specific antibody boost, we found a higher Delta-specific antibody response at the start of quarantine period, which correlated with higher Delta pseudovirus neutralizing capacity. Our findings indicate that a higher basal variant-specific antibody response in the mRNA-vaccinated individuals contributes to better protection against infections by the new emerging SARS-CoV-2 variants.https://doi.org/10.1038/s41598-023-46800-x |
| spellingShingle | Yun Shan Goh Siew-Wai Fong Matthew Zirui Tay Angeline Rouers Zi Wei Chang Jean-Marc Chavatte Pei Xiang Hor Chiew Yee Loh Yuling Huang Yong Jie Tan Bei Wang Eve Zi Xian Ngoh Siti Nazihah Mohd Salleh Raphael Tze Chuen Lee Georgina Lim NCID Study Group COVID-Study Group Sebastian Maurer-Stroh Cheng-I Wang Yee‐Sin Leo Raymond T. P. Lin Meng Chon Lam David C. Lye Barnaby Edward Young Lisa F. P. Ng Laurent Renia Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave Scientific Reports |
| title | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_full | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_fullStr | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_full_unstemmed | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_short | Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave |
| title_sort | higher delta variant specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mrna vaccines during the sars cov 2 delta wave |
| url | https://doi.org/10.1038/s41598-023-46800-x |
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