Identification and expression analysis of zebrafish glypicans during embryonic development.
Heparan sulfate Proteoglycans (HSPG) are ubiquitous molecules with indispensable functions in various biological processes. Glypicans are a family of HSPG's, characterized by a Gpi-anchor which directs them to the cell surface and/or extracellular matrix where they regulate growth factor signal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3828384?pdf=render |
| _version_ | 1828744000120553472 |
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| author | Mansi Gupta Michael Brand |
| author_facet | Mansi Gupta Michael Brand |
| author_sort | Mansi Gupta |
| collection | DOAJ |
| description | Heparan sulfate Proteoglycans (HSPG) are ubiquitous molecules with indispensable functions in various biological processes. Glypicans are a family of HSPG's, characterized by a Gpi-anchor which directs them to the cell surface and/or extracellular matrix where they regulate growth factor signaling during development and disease. We report the identification and expression pattern of glypican genes from zebrafish. The zebrafish genome contains 10 glypican homologs, as opposed to six in mammals, which are highly conserved and are phylogenetically related to the mammalian genes. Some of the fish glypicans like Gpc1a, Gpc3, Gpc4, Gpc6a and Gpc6b show conserved synteny with their mammalian cognate genes. Many glypicans are expressed during the gastrulation stage, but their expression becomes more tissue specific and defined during somitogenesis stages, particularly in the developing central nervous system. Existence of multiple glypican orthologs in fish with diverse expression pattern suggests highly specialized and/or redundant function of these genes during embryonic development. |
| first_indexed | 2024-04-13T01:49:07Z |
| format | Article |
| id | doaj.art-fca2278cf27d495ca7c542bc1afd4ee4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T01:49:07Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fca2278cf27d495ca7c542bc1afd4ee42022-12-22T03:07:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8082410.1371/journal.pone.0080824Identification and expression analysis of zebrafish glypicans during embryonic development.Mansi GuptaMichael BrandHeparan sulfate Proteoglycans (HSPG) are ubiquitous molecules with indispensable functions in various biological processes. Glypicans are a family of HSPG's, characterized by a Gpi-anchor which directs them to the cell surface and/or extracellular matrix where they regulate growth factor signaling during development and disease. We report the identification and expression pattern of glypican genes from zebrafish. The zebrafish genome contains 10 glypican homologs, as opposed to six in mammals, which are highly conserved and are phylogenetically related to the mammalian genes. Some of the fish glypicans like Gpc1a, Gpc3, Gpc4, Gpc6a and Gpc6b show conserved synteny with their mammalian cognate genes. Many glypicans are expressed during the gastrulation stage, but their expression becomes more tissue specific and defined during somitogenesis stages, particularly in the developing central nervous system. Existence of multiple glypican orthologs in fish with diverse expression pattern suggests highly specialized and/or redundant function of these genes during embryonic development.http://europepmc.org/articles/PMC3828384?pdf=render |
| spellingShingle | Mansi Gupta Michael Brand Identification and expression analysis of zebrafish glypicans during embryonic development. PLoS ONE |
| title | Identification and expression analysis of zebrafish glypicans during embryonic development. |
| title_full | Identification and expression analysis of zebrafish glypicans during embryonic development. |
| title_fullStr | Identification and expression analysis of zebrafish glypicans during embryonic development. |
| title_full_unstemmed | Identification and expression analysis of zebrafish glypicans during embryonic development. |
| title_short | Identification and expression analysis of zebrafish glypicans during embryonic development. |
| title_sort | identification and expression analysis of zebrafish glypicans during embryonic development |
| url | http://europepmc.org/articles/PMC3828384?pdf=render |
| work_keys_str_mv | AT mansigupta identificationandexpressionanalysisofzebrafishglypicansduringembryonicdevelopment AT michaelbrand identificationandexpressionanalysisofzebrafishglypicansduringembryonicdevelopment |