Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection
Abstract Background Spinal giant cell tumor (SGCT) is a relatively rare primary tumor. En bloc resection is the preferred surgical procedure for it due to its aggressiveness, meanwhile leading to more complications. We reported the characteristics of perioperative complications and local control of...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-023-06347-4 |
| _version_ | 1797846194218598400 |
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| author | Jiacheng Liu Panpan Hu Hua Zhou Ben Wang Xiaoguang Liu Fengliang Wu Yan Li Xiao Liu Lei Dang Yanchao Tang Zihe Li Zhongjun Liu Feng Wei |
| author_facet | Jiacheng Liu Panpan Hu Hua Zhou Ben Wang Xiaoguang Liu Fengliang Wu Yan Li Xiao Liu Lei Dang Yanchao Tang Zihe Li Zhongjun Liu Feng Wei |
| author_sort | Jiacheng Liu |
| collection | DOAJ |
| description | Abstract Background Spinal giant cell tumor (SGCT) is a relatively rare primary tumor. En bloc resection is the preferred surgical procedure for it due to its aggressiveness, meanwhile leading to more complications. We reported the characteristics of perioperative complications and local control of total tumor resection including en bloc resection and piecemeal resection for primary thoracic and lumbar spinal giant cell tumors in a single center over 10 years. Methods This is a retrospective cross-sectional and cohort study. Forty-one consecutive patients with SGCTs who underwent total tumor resection from 2010 to 2020 at our institution and were followed up for at least 24 months were reviewed. Surgery data, complication characteristics and local tumor control were collected and compared by different surgical procedure. Results Forty-one patients were included, consisting of 18 males and 23 females, with a mean age of 34.2 years. Thirty-one had thoracic vertebra lesions, and 10 had lumbar vertebra lesions. Thirty-five patients were primary cases, and 6 patients were recurrent cases. Eighteen patients were treated by total en bloc spondylectomy (TES), 12 patients underwent en bloc resection according to WBB surgical system, and 11 patients underwent piecemeal resection. The average surgical time was 498 min, and the mean estimated blood loss was 2145 ml. A total of 58 complications were recorded, and 30 patients (73.2%) had at least one perioperative complication. All patients were followed up after surgery for at least 2 years. A total of 6 cases had postoperative internal fixation failure, and 4 cases presented local tumor recurrence (9.8%). Conclusions Although the surgical technique is difficult and accompanied by a high rate of perioperative complications, en bloc resection can achieve favorable local control in SGCT. When it is too difficult to complete en bloc resection, thoroughly piecemeal resection without residual is also acceptable, given the relatively low recurrence rate. |
| first_indexed | 2024-04-09T17:51:00Z |
| format | Article |
| id | doaj.art-fca3a30e94974881b1b49000ff54d276 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-09T17:51:00Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-fca3a30e94974881b1b49000ff54d2762023-04-16T11:04:39ZengBMCBMC Musculoskeletal Disorders1471-24742023-04-012411910.1186/s12891-023-06347-4Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resectionJiacheng Liu0Panpan Hu1Hua Zhou2Ben Wang3Xiaoguang Liu4Fengliang Wu5Yan Li6Xiao Liu7Lei Dang8Yanchao Tang9Zihe Li10Zhongjun Liu11Feng Wei12Department of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalDepartment of Orthopedics and Beijing Key Laboratory of Spinal Disease Research, Peking University Third HospitalAbstract Background Spinal giant cell tumor (SGCT) is a relatively rare primary tumor. En bloc resection is the preferred surgical procedure for it due to its aggressiveness, meanwhile leading to more complications. We reported the characteristics of perioperative complications and local control of total tumor resection including en bloc resection and piecemeal resection for primary thoracic and lumbar spinal giant cell tumors in a single center over 10 years. Methods This is a retrospective cross-sectional and cohort study. Forty-one consecutive patients with SGCTs who underwent total tumor resection from 2010 to 2020 at our institution and were followed up for at least 24 months were reviewed. Surgery data, complication characteristics and local tumor control were collected and compared by different surgical procedure. Results Forty-one patients were included, consisting of 18 males and 23 females, with a mean age of 34.2 years. Thirty-one had thoracic vertebra lesions, and 10 had lumbar vertebra lesions. Thirty-five patients were primary cases, and 6 patients were recurrent cases. Eighteen patients were treated by total en bloc spondylectomy (TES), 12 patients underwent en bloc resection according to WBB surgical system, and 11 patients underwent piecemeal resection. The average surgical time was 498 min, and the mean estimated blood loss was 2145 ml. A total of 58 complications were recorded, and 30 patients (73.2%) had at least one perioperative complication. All patients were followed up after surgery for at least 2 years. A total of 6 cases had postoperative internal fixation failure, and 4 cases presented local tumor recurrence (9.8%). Conclusions Although the surgical technique is difficult and accompanied by a high rate of perioperative complications, en bloc resection can achieve favorable local control in SGCT. When it is too difficult to complete en bloc resection, thoroughly piecemeal resection without residual is also acceptable, given the relatively low recurrence rate.https://doi.org/10.1186/s12891-023-06347-4Spinal giant cell tumorEn bloc resectionComplicationRecurrence |
| spellingShingle | Jiacheng Liu Panpan Hu Hua Zhou Ben Wang Xiaoguang Liu Fengliang Wu Yan Li Xiao Liu Lei Dang Yanchao Tang Zihe Li Zhongjun Liu Feng Wei Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection BMC Musculoskeletal Disorders Spinal giant cell tumor En bloc resection Complication Recurrence |
| title | Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection |
| title_full | Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection |
| title_fullStr | Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection |
| title_full_unstemmed | Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection |
| title_short | Complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection |
| title_sort | complications and prognosis of primary thoracic and lumbar giant cell tumors treated by total tumor resection |
| topic | Spinal giant cell tumor En bloc resection Complication Recurrence |
| url | https://doi.org/10.1186/s12891-023-06347-4 |
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