Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge
The human gut microbiota include over 10 trillion microorganisms, such as bacteria, fungi, viruses, archaea, and protozoa. Many reports indicate the strong correlation between dysbiosis and the severity of cardiovascular diseases. Microbiota seem to interact with the host’s alloimmunity and may have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1588 |
| _version_ | 1827738508362514432 |
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| author | Katarzyna Olek Agnieszka Anna Kuczaj Szymon Warwas Tomasz Hrapkowicz Piotr Przybyłowski Marta Tanasiewicz |
| author_facet | Katarzyna Olek Agnieszka Anna Kuczaj Szymon Warwas Tomasz Hrapkowicz Piotr Przybyłowski Marta Tanasiewicz |
| author_sort | Katarzyna Olek |
| collection | DOAJ |
| description | The human gut microbiota include over 10 trillion microorganisms, such as bacteria, fungi, viruses, archaea, and protozoa. Many reports indicate the strong correlation between dysbiosis and the severity of cardiovascular diseases. Microbiota seem to interact with the host’s alloimmunity and may have an immunomodulatory role in graft rejection processes. In our study, we present the current state of the knowledge of microbiota in heart transplant recipients. We present up-to-date microbiota diagnostic methods, interactions between microbiota and immunosuppressive drugs, the immunomodulatory effects of dysbiosis, and the available strategies (experimental and clinical strategies) to modulate host microbiota. |
| first_indexed | 2024-03-11T02:45:19Z |
| format | Article |
| id | doaj.art-fca40d03a8124779b5cdc9fd3612ae5f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:45:19Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fca40d03a8124779b5cdc9fd3612ae5f2023-11-18T09:25:26ZengMDPI AGBiomedicines2227-90592023-05-01116158810.3390/biomedicines11061588Gut Microbiome in Patients after Heart Transplantation—Current State of KnowledgeKatarzyna Olek0Agnieszka Anna Kuczaj1Szymon Warwas2Tomasz Hrapkowicz3Piotr Przybyłowski4Marta Tanasiewicz5Department of Dental Propedeutics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, PolandDepartment of Cardiac Surgery, Transplantology, Vascular and Endovascular Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sklodowskiej 9, 41-800 Zabrze, PolandStudents’ Scientific Association Affiliated with the Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, PolandDepartment of Cardiac Surgery, Transplantology, Vascular and Endovascular Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sklodowskiej 9, 41-800 Zabrze, PolandDepartment of Cardiac Surgery, Transplantology, Vascular and Endovascular Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sklodowskiej 9, 41-800 Zabrze, PolandDepartment of Conservative Dentistry and Endodontics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Zabrze, PolandThe human gut microbiota include over 10 trillion microorganisms, such as bacteria, fungi, viruses, archaea, and protozoa. Many reports indicate the strong correlation between dysbiosis and the severity of cardiovascular diseases. Microbiota seem to interact with the host’s alloimmunity and may have an immunomodulatory role in graft rejection processes. In our study, we present the current state of the knowledge of microbiota in heart transplant recipients. We present up-to-date microbiota diagnostic methods, interactions between microbiota and immunosuppressive drugs, the immunomodulatory effects of dysbiosis, and the available strategies (experimental and clinical strategies) to modulate host microbiota.https://www.mdpi.com/2227-9059/11/6/1588dysbiosisgut microbiotaorthotopic heart transplantation |
| spellingShingle | Katarzyna Olek Agnieszka Anna Kuczaj Szymon Warwas Tomasz Hrapkowicz Piotr Przybyłowski Marta Tanasiewicz Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge Biomedicines dysbiosis gut microbiota orthotopic heart transplantation |
| title | Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge |
| title_full | Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge |
| title_fullStr | Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge |
| title_full_unstemmed | Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge |
| title_short | Gut Microbiome in Patients after Heart Transplantation—Current State of Knowledge |
| title_sort | gut microbiome in patients after heart transplantation current state of knowledge |
| topic | dysbiosis gut microbiota orthotopic heart transplantation |
| url | https://www.mdpi.com/2227-9059/11/6/1588 |
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