The effect of estrogen on brown adipose tissue activity in male rats
Abstract Objective Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-022-05910-x |
| _version_ | 1828855167975424000 |
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| author | W. Sievers C. Kettle R. A. Green L. Van Schaik M. W. Hale H. R. Irving D. R. Whelan J. A. Rathner |
| author_facet | W. Sievers C. Kettle R. A. Green L. Van Schaik M. W. Hale H. R. Irving D. R. Whelan J. A. Rathner |
| author_sort | W. Sievers |
| collection | DOAJ |
| description | Abstract Objective Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and centrally administered estrogen on thermogenesis, heart rate and mean arterial pressure in male rats. Thermogenesis was assessed by monitoring brown adipose tissue temperature. Results Peripherally administered estrogen elicited no significant effect on brown adipose tissue temperature, heart rate or mean arterial pressure. Centrally administered estrogen elicited a coincident increase in both brown adipose tissue and core temperature. Centrally administered estrogen also resulted in a decrease in mean arterial pressure but had no effect on heart rate. With the present data it is not possible to elucidate whether changes in temperature were the result of thermogenic or thermoregulatory mechanisms. |
| first_indexed | 2024-12-13T00:49:41Z |
| format | Article |
| id | doaj.art-fca5b4cced8a49dda2fa82e49c62f12c |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-13T00:49:41Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-fca5b4cced8a49dda2fa82e49c62f12c2022-12-22T00:04:57ZengBMCBMC Research Notes1756-05002022-02-011511710.1186/s13104-022-05910-xThe effect of estrogen on brown adipose tissue activity in male ratsW. Sievers0C. Kettle1R. A. Green2L. Van Schaik3M. W. Hale4H. R. Irving5D. R. Whelan6J. A. Rathner7Department of Pharmacy and Biomedical Sciences, La Trobe UniversityDepartment of Pharmacy and Biomedical Sciences, La Trobe UniversityDepartment of Pharmacy and Biomedical Sciences, La Trobe UniversityDepartment of Pharmacy and Biomedical Sciences, La Trobe UniversityDepartment of Psychology and Counselling, La Trobe UniversityDepartment of Pharmacy and Biomedical Sciences, La Trobe UniversityDepartment of Pharmacy and Biomedical Sciences, La Trobe UniversityDepartment of Pharmacy and Biomedical Sciences, La Trobe UniversityAbstract Objective Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and centrally administered estrogen on thermogenesis, heart rate and mean arterial pressure in male rats. Thermogenesis was assessed by monitoring brown adipose tissue temperature. Results Peripherally administered estrogen elicited no significant effect on brown adipose tissue temperature, heart rate or mean arterial pressure. Centrally administered estrogen elicited a coincident increase in both brown adipose tissue and core temperature. Centrally administered estrogen also resulted in a decrease in mean arterial pressure but had no effect on heart rate. With the present data it is not possible to elucidate whether changes in temperature were the result of thermogenic or thermoregulatory mechanisms.https://doi.org/10.1186/s13104-022-05910-xRodentsThermogenesisThermoregulationTranswomen |
| spellingShingle | W. Sievers C. Kettle R. A. Green L. Van Schaik M. W. Hale H. R. Irving D. R. Whelan J. A. Rathner The effect of estrogen on brown adipose tissue activity in male rats BMC Research Notes Rodents Thermogenesis Thermoregulation Transwomen |
| title | The effect of estrogen on brown adipose tissue activity in male rats |
| title_full | The effect of estrogen on brown adipose tissue activity in male rats |
| title_fullStr | The effect of estrogen on brown adipose tissue activity in male rats |
| title_full_unstemmed | The effect of estrogen on brown adipose tissue activity in male rats |
| title_short | The effect of estrogen on brown adipose tissue activity in male rats |
| title_sort | effect of estrogen on brown adipose tissue activity in male rats |
| topic | Rodents Thermogenesis Thermoregulation Transwomen |
| url | https://doi.org/10.1186/s13104-022-05910-x |
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