Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos
For a long time, the diagnostic approach to IA/Aspergillus disease has been a challenge. The definitive diagnosis is made by correct microbiological and/or histopathological documentation, undoubtedly the fundamental cornerstone for therapeutic decision-making. However, it is considered limited by l...
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| Format: | Article |
| Language: | English |
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Asociación Colombiana de Infectología
2022-07-01
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| Series: | Infectio |
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| _version_ | 1811181251222044672 |
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| author | Pilar Rivas-Pinedo |
| author_facet | Pilar Rivas-Pinedo |
| author_sort | Pilar Rivas-Pinedo |
| collection | DOAJ |
| description | For a long time, the diagnostic approach to IA/Aspergillus disease has been a challenge. The definitive diagnosis is made by correct microbiological and/or histopathological documentation, undoubtedly the fundamental cornerstone for therapeutic decision-making. However, it is considered limited by lack of sensi-tivity and speed, often being counterproductive, as in many cases invasive procedures are needed (e.g., fibrobronchoscopy [FBC] or tissue biopsy), which delays treatment and undermines survival of at-risk patients. This highlights the need for faster and more accurate diagnostic tools. Although novel serological and molecular methods have been developed that have demonstrated their potential to replace conventional diagnostic tests, inconsistencies in interpretation and validation among the different approaches limit their reproducibility and large-scale clinical application. However, whenever possible, an immunological and/or molecular diagnosis should be made, as it has proven useful in different detection and diagnostic strategies, which with an understanding of its strengths and limitations, and the standardization of the different techniques available, can be incorporated into care protocols and diagnostic algorithms, as an aid in adminis-tering and monitoring the different antifungal treatments and predicting possible clinical outcomes. Due to the limited sensitivity (SE) of many of the tests, and variations in the specificity (SP) of some of them, the combined use of several diagnostic tools during the high-risk period for invasive infection and/or during the early period in the course of IA/Aspergillus disease would allow an adequate diagnostic approach, provided that their results are interpreted together with the existing clinical and imaging information. |
| first_indexed | 2024-04-11T09:14:28Z |
| format | Article |
| id | doaj.art-fca630650b274ee49bf082c47dbb7065 |
| institution | Directory Open Access Journal |
| issn | 0123-9392 |
| language | English |
| last_indexed | 2024-04-11T09:14:28Z |
| publishDate | 2022-07-01 |
| publisher | Asociación Colombiana de Infectología |
| record_format | Article |
| series | Infectio |
| spelling | doaj.art-fca630650b274ee49bf082c47dbb70652022-12-22T04:32:24ZengAsociación Colombiana de InfectologíaInfectio0123-93922022-07-01263262295https://doi.org/10.22354/24223794.1062Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricosPilar Rivas-Pinedo0https://orcid.org/0000-0002-6034-3182icología Médica y Diagnóstica, Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia. Bogotá, Colombia. For a long time, the diagnostic approach to IA/Aspergillus disease has been a challenge. The definitive diagnosis is made by correct microbiological and/or histopathological documentation, undoubtedly the fundamental cornerstone for therapeutic decision-making. However, it is considered limited by lack of sensi-tivity and speed, often being counterproductive, as in many cases invasive procedures are needed (e.g., fibrobronchoscopy [FBC] or tissue biopsy), which delays treatment and undermines survival of at-risk patients. This highlights the need for faster and more accurate diagnostic tools. Although novel serological and molecular methods have been developed that have demonstrated their potential to replace conventional diagnostic tests, inconsistencies in interpretation and validation among the different approaches limit their reproducibility and large-scale clinical application. However, whenever possible, an immunological and/or molecular diagnosis should be made, as it has proven useful in different detection and diagnostic strategies, which with an understanding of its strengths and limitations, and the standardization of the different techniques available, can be incorporated into care protocols and diagnostic algorithms, as an aid in adminis-tering and monitoring the different antifungal treatments and predicting possible clinical outcomes. Due to the limited sensitivity (SE) of many of the tests, and variations in the specificity (SP) of some of them, the combined use of several diagnostic tools during the high-risk period for invasive infection and/or during the early period in the course of IA/Aspergillus disease would allow an adequate diagnostic approach, provided that their results are interpreted together with the existing clinical and imaging information.aspergillosis; aspergillus; guidelines; diagnosis; aspergillus resistance; azole resistance; antifungal resistance; galactomannan; aspergillus pcr |
| spellingShingle | Pilar Rivas-Pinedo Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos Infectio aspergillosis; aspergillus; guidelines; diagnosis; aspergillus resistance; azole resistance; antifungal resistance; galactomannan; aspergillus pcr |
| title | Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos |
| title_full | Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos |
| title_fullStr | Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos |
| title_full_unstemmed | Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos |
| title_short | Sección 1. Consenso colombiano para el diagnóstico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediátricos |
| title_sort | seccion 1 consenso colombiano para el diagnostico y seguimiento de la aspergilosis invasora y de la enfermedad aspergilar en pacientes adultos y pediatricos |
| topic | aspergillosis; aspergillus; guidelines; diagnosis; aspergillus resistance; azole resistance; antifungal resistance; galactomannan; aspergillus pcr |
| work_keys_str_mv | AT pilarrivaspinedo seccion1consensocolombianoparaeldiagnosticoyseguimientodelaaspergilosisinvasoraydelaenfermedadaspergilarenpacientesadultosypediatricos |