Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K/AKT/mTOR signaling pathway

Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K/AKT/mTOR signaling pathway

Vasculogenic mimicry (VM) differs from the classical tumor angiogenesis model. VM does not depend on endothelial cells; instead, highly aggressive tumor cells mimic endothelial cells to form a vascular-like channel structure. VM mediated by tumor cells is significantly and positively associated with...

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Bibliographic Details
Main Authors: Ju Huang, Congcong Wang, Yixuan Hou, Yuanyuan Tian, Yanru Li, Haiying Zhang, Lihong Zhang, Wei Li
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Thrombospondin 2
Vasculogenic mimicry
PI3K/AKT/mTOR signaling pathway
CD36
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012532

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