Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations
The efficacy of ImarsilTM in mitigating the effects of aflatoxin M1 (AFM1) in cow's milk on hematological and histopathological parameters was investigated in this study. Seventy-two albino rats were randomly allocated to four treatment groups A - D in a six-week study. Rats in all groups were...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2023-12-01
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| Series: | Industria: Jurnal Teknologi dan Manajemen Agroindustri |
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| Online Access: | https://industria.ub.ac.id/index.php/industri/article/view/5512 |
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| author | Adelodun Lawrence Kolapo Flora Oluwafemi Sarafadeen Kareem Abosede Oyeyemi Fawole Olufunmilayo Ebunoluwa Adejumo |
| author_facet | Adelodun Lawrence Kolapo Flora Oluwafemi Sarafadeen Kareem Abosede Oyeyemi Fawole Olufunmilayo Ebunoluwa Adejumo |
| author_sort | Adelodun Lawrence Kolapo |
| collection | DOAJ |
| description | The efficacy of ImarsilTM in mitigating the effects of aflatoxin M1 (AFM1) in cow's milk on hematological and histopathological parameters was investigated in this study. Seventy-two albino rats were randomly allocated to four treatment groups A - D in a six-week study. Rats in all groups were fed standard ration. In addition, 2 mL of clean distilled water, 2 mL of milk, 2 mL of AFM1 contaminated milk (456 ng/L), and 2 mL of AFM1 contaminated milk (456 ng/L) treated with ImarsilTM at 2% dosage rate were added to the ration of animals in groups A, B, C, and D respectively. The results of the investigation showed that rats in Group C developed a significant (p<0.05) lower weight. Packed Cell Volume (%), Hemoglobin (g/dL), Red Blood Cell (106/mm3), Mean Corpuscular Volume (fL), Mean Corpuscular Hemoglobin (pg), and Mean Corpuscular Hemoglobin Concentration (g/dL) were not significantly different (p>0.05) among the different groups. In group C, a significant reduction (p<0.05) occurred in the white blood cell (103/mm3) (12.90 - 8.63), and lymphocytes (87.00 - 74.33%) counts while the neutrophils (%) increased from 13.00 to 25.67. In contrast to those in Group C, tissue sections from Group D showed no histological lesions. Therefore, ImarsilTM represents an effective and safe adsorbent for the remediation of AFM1-contaminated milk. |
| first_indexed | 2024-03-07T23:50:39Z |
| format | Article |
| id | doaj.art-fca7da87ca184bbc9749b6151cf827c1 |
| institution | Directory Open Access Journal |
| issn | 2252-7877 2549-3892 |
| language | English |
| last_indexed | 2024-03-07T23:50:39Z |
| publishDate | 2023-12-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Industria: Jurnal Teknologi dan Manajemen Agroindustri |
| spelling | doaj.art-fca7da87ca184bbc9749b6151cf827c12024-02-19T08:12:23ZengUniversity of BrawijayaIndustria: Jurnal Teknologi dan Manajemen Agroindustri2252-78772549-38922023-12-0112218019110.21776/ub.industria.2023.012.02.7Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological AlterationsAdelodun Lawrence Kolapo0Flora Oluwafemi1Sarafadeen Kareem2Abosede Oyeyemi Fawole3Olufunmilayo Ebunoluwa Adejumo4Augustine UniversityFederal UniversityFederal UniversityThe PolytechnicOlabisi Onabanjo UniversityThe efficacy of ImarsilTM in mitigating the effects of aflatoxin M1 (AFM1) in cow's milk on hematological and histopathological parameters was investigated in this study. Seventy-two albino rats were randomly allocated to four treatment groups A - D in a six-week study. Rats in all groups were fed standard ration. In addition, 2 mL of clean distilled water, 2 mL of milk, 2 mL of AFM1 contaminated milk (456 ng/L), and 2 mL of AFM1 contaminated milk (456 ng/L) treated with ImarsilTM at 2% dosage rate were added to the ration of animals in groups A, B, C, and D respectively. The results of the investigation showed that rats in Group C developed a significant (p<0.05) lower weight. Packed Cell Volume (%), Hemoglobin (g/dL), Red Blood Cell (106/mm3), Mean Corpuscular Volume (fL), Mean Corpuscular Hemoglobin (pg), and Mean Corpuscular Hemoglobin Concentration (g/dL) were not significantly different (p>0.05) among the different groups. In group C, a significant reduction (p<0.05) occurred in the white blood cell (103/mm3) (12.90 - 8.63), and lymphocytes (87.00 - 74.33%) counts while the neutrophils (%) increased from 13.00 to 25.67. In contrast to those in Group C, tissue sections from Group D showed no histological lesions. Therefore, ImarsilTM represents an effective and safe adsorbent for the remediation of AFM1-contaminated milk.https://industria.ub.ac.id/index.php/industri/article/view/5512adsorbentsaflatoxin m1cow’s milkhematological parameters and histopathological changesimarsiltm |
| spellingShingle | Adelodun Lawrence Kolapo Flora Oluwafemi Sarafadeen Kareem Abosede Oyeyemi Fawole Olufunmilayo Ebunoluwa Adejumo Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations Industria: Jurnal Teknologi dan Manajemen Agroindustri adsorbents aflatoxin m1 cow’s milk hematological parameters and histopathological changes imarsiltm |
| title | Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations |
| title_full | Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations |
| title_fullStr | Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations |
| title_full_unstemmed | Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations |
| title_short | Impact of ImarsilTM Adsorption on Aflatoxin M1 (AFM1) Levels in Cow's Milk: Analyzing Hematological Parameters and Histopathological Alterations |
| title_sort | impact of imarsiltm adsorption on aflatoxin m1 afm1 levels in cow s milk analyzing hematological parameters and histopathological alterations |
| topic | adsorbents aflatoxin m1 cow’s milk hematological parameters and histopathological changes imarsiltm |
| url | https://industria.ub.ac.id/index.php/industri/article/view/5512 |
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