COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation
Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 memory T cell pool, thereby permitting reactivation...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32324-x |
| _version_ | 1811215748236836864 |
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| author | Matthias Reinscheid Hendrik Luxenburger Vivien Karl Anne Graeser Sebastian Giese Kevin Ciminski David B. Reeg Valerie Oberhardt Natascha Roehlen Julia Lang-Meli Kathrin Heim Nina Gross Christina Baum Siegbert Rieg Claudius Speer Florian Emmerich Susanne Breisinger Daniel Steinmann Bertram Bengsch Tobias Boettler Georg Kochs Martin Schwemmle Robert Thimme Christoph Neumann-Haefelin Maike Hofmann |
| author_facet | Matthias Reinscheid Hendrik Luxenburger Vivien Karl Anne Graeser Sebastian Giese Kevin Ciminski David B. Reeg Valerie Oberhardt Natascha Roehlen Julia Lang-Meli Kathrin Heim Nina Gross Christina Baum Siegbert Rieg Claudius Speer Florian Emmerich Susanne Breisinger Daniel Steinmann Bertram Bengsch Tobias Boettler Georg Kochs Martin Schwemmle Robert Thimme Christoph Neumann-Haefelin Maike Hofmann |
| author_sort | Matthias Reinscheid |
| collection | DOAJ |
| description | Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 memory T cell pool, thereby permitting reactivation of spike-specific CD8 + T cells upon breakthrough infection or 4th vaccination. |
| first_indexed | 2024-04-12T06:27:37Z |
| format | Article |
| id | doaj.art-fca8aca08c224586bb686b0fe9b5ffd3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T06:27:37Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fca8aca08c224586bb686b0fe9b5ffd32022-12-22T03:44:06ZengNature PortfolioNature Communications2041-17232022-08-0113111110.1038/s41467-022-32324-xCOVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivationMatthias Reinscheid0Hendrik Luxenburger1Vivien Karl2Anne Graeser3Sebastian Giese4Kevin Ciminski5David B. Reeg6Valerie Oberhardt7Natascha Roehlen8Julia Lang-Meli9Kathrin Heim10Nina Gross11Christina Baum12Siegbert Rieg13Claudius Speer14Florian Emmerich15Susanne Breisinger16Daniel Steinmann17Bertram Bengsch18Tobias Boettler19Georg Kochs20Martin Schwemmle21Robert Thimme22Christoph Neumann-Haefelin23Maike Hofmann24Department of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Nephrology, University of HeidelbergInstitute for Transfusion Medicine and Gene Therapy, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgOccupational Medical Service, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgOccupational Medical Service, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgInstitute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Freiburg University Medical Center, Faculty of Medicine, University of FreiburgVaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 memory T cell pool, thereby permitting reactivation of spike-specific CD8 + T cells upon breakthrough infection or 4th vaccination.https://doi.org/10.1038/s41467-022-32324-x |
| spellingShingle | Matthias Reinscheid Hendrik Luxenburger Vivien Karl Anne Graeser Sebastian Giese Kevin Ciminski David B. Reeg Valerie Oberhardt Natascha Roehlen Julia Lang-Meli Kathrin Heim Nina Gross Christina Baum Siegbert Rieg Claudius Speer Florian Emmerich Susanne Breisinger Daniel Steinmann Bertram Bengsch Tobias Boettler Georg Kochs Martin Schwemmle Robert Thimme Christoph Neumann-Haefelin Maike Hofmann COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation Nature Communications |
| title | COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation |
| title_full | COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation |
| title_fullStr | COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation |
| title_full_unstemmed | COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation |
| title_short | COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation |
| title_sort | covid 19 mrna booster vaccine induces transient cd8 t effector cell responses while conserving the memory pool for subsequent reactivation |
| url | https://doi.org/10.1038/s41467-022-32324-x |
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