Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer
The objective of this study is to evaluate the relationship between discoidin domain receptor 2 (DDR2) and miR-182 expression with response to platinum-based chemotherapy and survival in women with high-grade serous ovarian cancer (HGSOC). We evaluated 78 women with HGSOC stages I-IV, diagnosed betw...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IOS Press
2019-01-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428318823988 |
| _version_ | 1818646448827269120 |
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| author | Susana Ramalho Liliana AL De Angelo Andrade Cássio Cardoso Filho Rodrigo de Andrade Natal Marina Pavanello Amanda Canato Ferracini Luis Felipe Sallum Luis Otávio Sarian Sophie Derchain |
| author_facet | Susana Ramalho Liliana AL De Angelo Andrade Cássio Cardoso Filho Rodrigo de Andrade Natal Marina Pavanello Amanda Canato Ferracini Luis Felipe Sallum Luis Otávio Sarian Sophie Derchain |
| author_sort | Susana Ramalho |
| collection | DOAJ |
| description | The objective of this study is to evaluate the relationship between discoidin domain receptor 2 (DDR2) and miR-182 expression with response to platinum-based chemotherapy and survival in women with high-grade serous ovarian cancer (HGSOC). We evaluated 78 women with HGSOC stages I-IV, diagnosed between 1996 and 2013, and followed up until 2016. DDR2 expression was assessed using immunohistochemistry on tissue microarray slides. The microRNAs were evaluated by qRT-PCR. DDR2 expression was high in 11 (14.1%) women. PFS was significantly lower in women with FIGO stage I/II – versus III/IV, post-surgery residual disease and high expression of DDR2. Women with postsurgery residual disease, FIGO stage I/II – versus III/IV and DDR2 expression had worse OS, but only post-surgery residual disease remained an independent prognostic factor for worse OS in multivariable analysis. miR-182 expression levels were significantly lower in patients harboring tumors with higher expression of DDR2 (p < 0.001). In this relatively large cohort of women with HSGOC, higher DDR2 expression was associated with lower miR-182 levels and worse PFS, suggesting that these molecules may be associated with mechanisms of HGSOC progression. |
| first_indexed | 2024-12-17T00:46:48Z |
| format | Article |
| id | doaj.art-fca9c23c17d841d5b971a747e08e84ed |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-17T00:46:48Z |
| publishDate | 2019-01-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-fca9c23c17d841d5b971a747e08e84ed2022-12-21T22:09:53ZengIOS PressTumor Biology1423-03802019-01-014110.1177/1010428318823988Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancerSusana Ramalho0Liliana AL De Angelo Andrade1Cássio Cardoso Filho2Rodrigo de Andrade Natal3Marina Pavanello4Amanda Canato Ferracini5Luis Felipe Sallum6Luis Otávio Sarian7Sophie Derchain8Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilDepartment of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilLaboratory of Investigative and Molecular Pathology (LAPE), Faculty of Medical Sciences, University of Campinas, Campinas, BrazilPostgraduate Program in Medical Sciences, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilPostgraduate Program in Medical Sciences, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilDepartment of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, BrazilThe objective of this study is to evaluate the relationship between discoidin domain receptor 2 (DDR2) and miR-182 expression with response to platinum-based chemotherapy and survival in women with high-grade serous ovarian cancer (HGSOC). We evaluated 78 women with HGSOC stages I-IV, diagnosed between 1996 and 2013, and followed up until 2016. DDR2 expression was assessed using immunohistochemistry on tissue microarray slides. The microRNAs were evaluated by qRT-PCR. DDR2 expression was high in 11 (14.1%) women. PFS was significantly lower in women with FIGO stage I/II – versus III/IV, post-surgery residual disease and high expression of DDR2. Women with postsurgery residual disease, FIGO stage I/II – versus III/IV and DDR2 expression had worse OS, but only post-surgery residual disease remained an independent prognostic factor for worse OS in multivariable analysis. miR-182 expression levels were significantly lower in patients harboring tumors with higher expression of DDR2 (p < 0.001). In this relatively large cohort of women with HSGOC, higher DDR2 expression was associated with lower miR-182 levels and worse PFS, suggesting that these molecules may be associated with mechanisms of HGSOC progression.https://doi.org/10.1177/1010428318823988 |
| spellingShingle | Susana Ramalho Liliana AL De Angelo Andrade Cássio Cardoso Filho Rodrigo de Andrade Natal Marina Pavanello Amanda Canato Ferracini Luis Felipe Sallum Luis Otávio Sarian Sophie Derchain Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer Tumor Biology |
| title | Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer |
| title_full | Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer |
| title_fullStr | Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer |
| title_full_unstemmed | Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer |
| title_short | Role of discoidin domain receptor 2 (DDR2) and microRNA-182 in survival of women with high-grade serous ovarian cancer |
| title_sort | role of discoidin domain receptor 2 ddr2 and microrna 182 in survival of women with high grade serous ovarian cancer |
| url | https://doi.org/10.1177/1010428318823988 |
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