Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers
Christina H Son,1 Gini F Fleming,2 John W Moroney3 1Department of Radiation & Cellular Oncology, University of Chicago Medicine, 2Section of Hematology/Oncology, Department of Medicine, University of Chicago Medicine, 3Section of Gynecologic Oncology, Department of Obstetrics & Gynec...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-10-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/potential-role-of-radiation-therapy-in-augmenting-the-activity-of-immu-peer-reviewed-article-CMAR |
| _version_ | 1818612228864081920 |
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| author | Son CH Fleming GF Moroney JW |
| author_facet | Son CH Fleming GF Moroney JW |
| author_sort | Son CH |
| collection | DOAJ |
| description | Christina H Son,1 Gini F Fleming,2 John W Moroney3 1Department of Radiation & Cellular Oncology, University of Chicago Medicine, 2Section of Hematology/Oncology, Department of Medicine, University of Chicago Medicine, 3Section of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Chicago Medicine, Chicago, IL, USA Abstract: Immune checkpoint inhibitors have become an area of intense interest in oncology and are actively being studied in a variety of cancer types with a wide range of success. In vitro data suggest mechanisms by which radiation can activate the immune system, and ongoing studies are exploring the potential interaction of checkpoint inhibitors with radiotherapy in both preclinical and clinical settings. Gynecologic malignancies are a heterogeneous group of tumors with varying prognoses, intrinsic immunogenicity, and potential for response to immune-based therapies. In this review, we focus on the rationale for immunotherapy and opportunities for augmentation by photon radiotherapy in cancers of the cervix, endometrium, and ovary. Keywords: immunotherapy, gynecologic, PD-1, radiation |
| first_indexed | 2024-12-16T15:42:54Z |
| format | Article |
| id | doaj.art-fcaa3bac0df04072a913a91490b708cd |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-16T15:42:54Z |
| publishDate | 2017-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-fcaa3bac0df04072a913a91490b708cd2022-12-21T22:25:55ZengDove Medical PressCancer Management and Research1179-13222017-10-01Volume 955356335385Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancersSon CHFleming GFMoroney JWChristina H Son,1 Gini F Fleming,2 John W Moroney3 1Department of Radiation & Cellular Oncology, University of Chicago Medicine, 2Section of Hematology/Oncology, Department of Medicine, University of Chicago Medicine, 3Section of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Chicago Medicine, Chicago, IL, USA Abstract: Immune checkpoint inhibitors have become an area of intense interest in oncology and are actively being studied in a variety of cancer types with a wide range of success. In vitro data suggest mechanisms by which radiation can activate the immune system, and ongoing studies are exploring the potential interaction of checkpoint inhibitors with radiotherapy in both preclinical and clinical settings. Gynecologic malignancies are a heterogeneous group of tumors with varying prognoses, intrinsic immunogenicity, and potential for response to immune-based therapies. In this review, we focus on the rationale for immunotherapy and opportunities for augmentation by photon radiotherapy in cancers of the cervix, endometrium, and ovary. Keywords: immunotherapy, gynecologic, PD-1, radiationhttps://www.dovepress.com/potential-role-of-radiation-therapy-in-augmenting-the-activity-of-immu-peer-reviewed-article-CMARimmunotherapygynecologicPD-1radiation |
| spellingShingle | Son CH Fleming GF Moroney JW Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers Cancer Management and Research immunotherapy gynecologic PD-1 radiation |
| title | Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers |
| title_full | Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers |
| title_fullStr | Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers |
| title_full_unstemmed | Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers |
| title_short | Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers |
| title_sort | potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers |
| topic | immunotherapy gynecologic PD-1 radiation |
| url | https://www.dovepress.com/potential-role-of-radiation-therapy-in-augmenting-the-activity-of-immu-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT sonch potentialroleofradiationtherapyinaugmentingtheactivityofimmunotherapyforgynecologiccancers AT fleminggf potentialroleofradiationtherapyinaugmentingtheactivityofimmunotherapyforgynecologiccancers AT moroneyjw potentialroleofradiationtherapyinaugmentingtheactivityofimmunotherapyforgynecologiccancers |