Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status
ObjectiveThe application of radiofrequency ablation (RFA) for recurrent thyroid cancer has been demonstrated to effectively manage lesions at critical locations, such as abutting the trachea, with limited complications. Comprehensive investigation of both biochemical (B) and structural (S) change af...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.933931/full |
| _version_ | 1818507704693424128 |
|---|---|
| author | Wen-Chieh Chen Chen-Kai Chou Yen-Hsiang Chang Pi-Ling Chiang Lay-San Lim Shun-Yu Chi Sheng-Dean Luo Wei-Che Lin |
| author_facet | Wen-Chieh Chen Chen-Kai Chou Yen-Hsiang Chang Pi-Ling Chiang Lay-San Lim Shun-Yu Chi Sheng-Dean Luo Wei-Che Lin |
| author_sort | Wen-Chieh Chen |
| collection | DOAJ |
| description | ObjectiveThe application of radiofrequency ablation (RFA) for recurrent thyroid cancer has been demonstrated to effectively manage lesions at critical locations, such as abutting the trachea, with limited complications. Comprehensive investigation of both biochemical (B) and structural (S) change after RFA remains limited. We herein present the first single-center experience of RFA for the treatment of locoregional recurrent thyroid cancer in Taiwan.Design23 patients were enrolled, and the treatment responses after RFA were divided into four groups (E, S(+), B(+), and SB(+)), and then compared. The RFA technique, follow-up strategy, changes in pre-and post-operative status, and complications are presented. The volume reduction rate at 1, 3, and 6 months, and the differing responses between lesions abutting/not abutting the trachea are also discussed.ResultsIn patients with pre-RFA structural and biochemical incomplete (SB(+)) status, presenting with lesion with an initial maximum diameter of >3.2cm, a higher rate of structural incomplete status at the 6-month follow-up was noted in ROC analysis, with a sensitivity of 57% and specificity of 91%. Favorable structural remission after RFA was noted, and 60.9% of patients achieved biochemical complete status. No significant correlation was noted between the trachea-abutted lesion number and complete remission (p= 0.474). No significant difference in RFA efficacy was noted between the lesions abutting/not abutting the trachea.ConclusionsThis retrospective study reveals that RFA can achieve both structural and biochemical improvements for locoregionally recurrent thyroid cancer, with a low complication rate. Nearly half of the patients achieved an excellent response after RFA, while a favorable treatment response can be achieved despite the lesion abutting the trachea, with a mean VRR of 84.74%. |
| first_indexed | 2024-12-10T22:21:46Z |
| format | Article |
| id | doaj.art-fcacc3c9cc8341369fa64de77d9f3fea |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T22:21:46Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-fcacc3c9cc8341369fa64de77d9f3fea2022-12-22T01:31:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.933931933931Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete statusWen-Chieh Chen0Chen-Kai Chou1Yen-Hsiang Chang2Pi-Ling Chiang3Lay-San Lim4Shun-Yu Chi5Sheng-Dean Luo6Wei-Che Lin7Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of General Surgery and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanObjectiveThe application of radiofrequency ablation (RFA) for recurrent thyroid cancer has been demonstrated to effectively manage lesions at critical locations, such as abutting the trachea, with limited complications. Comprehensive investigation of both biochemical (B) and structural (S) change after RFA remains limited. We herein present the first single-center experience of RFA for the treatment of locoregional recurrent thyroid cancer in Taiwan.Design23 patients were enrolled, and the treatment responses after RFA were divided into four groups (E, S(+), B(+), and SB(+)), and then compared. The RFA technique, follow-up strategy, changes in pre-and post-operative status, and complications are presented. The volume reduction rate at 1, 3, and 6 months, and the differing responses between lesions abutting/not abutting the trachea are also discussed.ResultsIn patients with pre-RFA structural and biochemical incomplete (SB(+)) status, presenting with lesion with an initial maximum diameter of >3.2cm, a higher rate of structural incomplete status at the 6-month follow-up was noted in ROC analysis, with a sensitivity of 57% and specificity of 91%. Favorable structural remission after RFA was noted, and 60.9% of patients achieved biochemical complete status. No significant correlation was noted between the trachea-abutted lesion number and complete remission (p= 0.474). No significant difference in RFA efficacy was noted between the lesions abutting/not abutting the trachea.ConclusionsThis retrospective study reveals that RFA can achieve both structural and biochemical improvements for locoregionally recurrent thyroid cancer, with a low complication rate. Nearly half of the patients achieved an excellent response after RFA, while a favorable treatment response can be achieved despite the lesion abutting the trachea, with a mean VRR of 84.74%.https://www.frontiersin.org/articles/10.3389/fendo.2022.933931/fullmetastasis thyroid cancerultrasoundradiofrequency ablationtracheal invasionbiochemical incomplete response |
| spellingShingle | Wen-Chieh Chen Chen-Kai Chou Yen-Hsiang Chang Pi-Ling Chiang Lay-San Lim Shun-Yu Chi Sheng-Dean Luo Wei-Che Lin Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status Frontiers in Endocrinology metastasis thyroid cancer ultrasound radiofrequency ablation tracheal invasion biochemical incomplete response |
| title | Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status |
| title_full | Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status |
| title_fullStr | Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status |
| title_full_unstemmed | Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status |
| title_short | Efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status |
| title_sort | efficacy of radiofrequency ablation for metastatic papillary thyroid cancer with and without initial biochemical complete status |
| topic | metastasis thyroid cancer ultrasound radiofrequency ablation tracheal invasion biochemical incomplete response |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.933931/full |
| work_keys_str_mv | AT wenchiehchen efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT chenkaichou efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT yenhsiangchang efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT pilingchiang efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT laysanlim efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT shunyuchi efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT shengdeanluo efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus AT weichelin efficacyofradiofrequencyablationformetastaticpapillarythyroidcancerwithandwithoutinitialbiochemicalcompletestatus |