Pravastatin and Gemfibrozil Modulate Differently Hepatic and Colonic Mitochondrial Respiration in Tissue Homogenates from Healthy Rats

Pravastatin and Gemfibrozil Modulate Differently Hepatic and Colonic Mitochondrial Respiration in Tissue Homogenates from Healthy Rats

Statins and fibrates are widely used for the management of hypertriglyceridemia but they also have limitations, mostly due to pharmacokinetic interactions or side effects. It is conceivable that some adverse events like liver dysfunction or gastrointestinal discomfort are caused by mitochondrial dys...

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Bibliographic Details
Main Authors: Anna Herminghaus, Eric Laser, Jan Schulz, Richard Truse, Christian Vollmer, Inge Bauer, Olaf Picker
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
pravastatin
gemfibrozil
liver
colon
mitochondrial function
Online Access:https://www.mdpi.com/2073-4409/8/9/983

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