Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
While post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 on transcription at base-pair resolution in yeast.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03006-4 |
| _version_ | 1818858443213111296 |
|---|---|
| author | Gregory T. Booth Pabitra K. Parua Miriam Sansó Robert P. Fisher John T. Lis |
| author_facet | Gregory T. Booth Pabitra K. Parua Miriam Sansó Robert P. Fisher John T. Lis |
| author_sort | Gregory T. Booth |
| collection | DOAJ |
| description | While post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 on transcription at base-pair resolution in yeast. |
| first_indexed | 2024-12-19T08:56:22Z |
| format | Article |
| id | doaj.art-fcb0fae25f044fe193746041c137258a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:56:22Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fcb0fae25f044fe193746041c137258a2022-12-21T20:28:37ZengNature PortfolioNature Communications2041-17232018-02-019111010.1038/s41467-018-03006-4Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeastGregory T. Booth0Pabitra K. Parua1Miriam Sansó2Robert P. Fisher3John T. Lis4Department of Molecular Biology and Genetics, Cornell UniversityDepartment of Oncological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Oncological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Oncological Sciences, Icahn School of Medicine at Mount SinaiDepartment of Molecular Biology and Genetics, Cornell UniversityWhile post-translational modifications of the RNA polymerase II complex regulate gene expression, the exact mechanism remains unknown. Here, the authors use altered-specificity kinase mutations to examine the role of Cdk9, Mcs6/Cdk7, and Lsk1/Cdk12 on transcription at base-pair resolution in yeast.https://doi.org/10.1038/s41467-018-03006-4 |
| spellingShingle | Gregory T. Booth Pabitra K. Parua Miriam Sansó Robert P. Fisher John T. Lis Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast Nature Communications |
| title | Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast |
| title_full | Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast |
| title_fullStr | Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast |
| title_full_unstemmed | Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast |
| title_short | Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast |
| title_sort | cdk9 regulates a promoter proximal checkpoint to modulate rna polymerase ii elongation rate in fission yeast |
| url | https://doi.org/10.1038/s41467-018-03006-4 |
| work_keys_str_mv | AT gregorytbooth cdk9regulatesapromoterproximalcheckpointtomodulaternapolymeraseiielongationrateinfissionyeast AT pabitrakparua cdk9regulatesapromoterproximalcheckpointtomodulaternapolymeraseiielongationrateinfissionyeast AT miriamsanso cdk9regulatesapromoterproximalcheckpointtomodulaternapolymeraseiielongationrateinfissionyeast AT robertpfisher cdk9regulatesapromoterproximalcheckpointtomodulaternapolymeraseiielongationrateinfissionyeast AT johntlis cdk9regulatesapromoterproximalcheckpointtomodulaternapolymeraseiielongationrateinfissionyeast |