Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory.
Motor and cognitive aging can severely affect life quality of elderly people and burden health care systems. In search for diagnostic behavioral biomarkers, it has been suggested that walking speed can predict forms of cognitive decline, but in humans, it remains challenging to separate the effects...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293252&type=printable |
| _version_ | 1797209663105662976 |
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| author | Jessica Thiem Maria Viskadourou Alexandros Gaitanidis Dimitrios J Stravopodis Roland Strauß Carsten Duch Christos Consoulas |
| author_facet | Jessica Thiem Maria Viskadourou Alexandros Gaitanidis Dimitrios J Stravopodis Roland Strauß Carsten Duch Christos Consoulas |
| author_sort | Jessica Thiem |
| collection | DOAJ |
| description | Motor and cognitive aging can severely affect life quality of elderly people and burden health care systems. In search for diagnostic behavioral biomarkers, it has been suggested that walking speed can predict forms of cognitive decline, but in humans, it remains challenging to separate the effects of biological aging and lifestyle. We examined a possible association of motor and cognitive decline in Drosophila, a genetic model organism of healthy aging. Long term courtship memory is present in young male flies but absent already during mid life (4-8 weeks). By contrast, courtship learning index and short term memory (STM) are surprisingly robust and remain stable through mid (4-8 weeks) and healthy late life (>8 weeks), until courtship performance collapses suddenly at ~4.5 days prior to death. By contrast, climbing speed declines gradually during late life (>8 weeks). The collapse of courtship performance and short term memory close to the end of life occur later and progress with a different time course than the gradual late life decline in climbing speed. Thus, during healthy aging in male Drosophila, climbing and courtship motor behaviors decline differentially. Moreover, cognitive and motor performances decline at different time courses. Differential behavioral decline during aging may indicate different underlying causes, or alternatively, a common cause but different thresholds for defects in different behaviors. |
| first_indexed | 2024-04-24T09:58:16Z |
| format | Article |
| id | doaj.art-fcb266e066594bb592777b0c8525efdd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T09:58:16Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fcb266e066594bb592777b0c8525efdd2024-04-14T05:31:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e029325210.1371/journal.pone.0293252Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory.Jessica ThiemMaria ViskadourouAlexandros GaitanidisDimitrios J StravopodisRoland StraußCarsten DuchChristos ConsoulasMotor and cognitive aging can severely affect life quality of elderly people and burden health care systems. In search for diagnostic behavioral biomarkers, it has been suggested that walking speed can predict forms of cognitive decline, but in humans, it remains challenging to separate the effects of biological aging and lifestyle. We examined a possible association of motor and cognitive decline in Drosophila, a genetic model organism of healthy aging. Long term courtship memory is present in young male flies but absent already during mid life (4-8 weeks). By contrast, courtship learning index and short term memory (STM) are surprisingly robust and remain stable through mid (4-8 weeks) and healthy late life (>8 weeks), until courtship performance collapses suddenly at ~4.5 days prior to death. By contrast, climbing speed declines gradually during late life (>8 weeks). The collapse of courtship performance and short term memory close to the end of life occur later and progress with a different time course than the gradual late life decline in climbing speed. Thus, during healthy aging in male Drosophila, climbing and courtship motor behaviors decline differentially. Moreover, cognitive and motor performances decline at different time courses. Differential behavioral decline during aging may indicate different underlying causes, or alternatively, a common cause but different thresholds for defects in different behaviors.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293252&type=printable |
| spellingShingle | Jessica Thiem Maria Viskadourou Alexandros Gaitanidis Dimitrios J Stravopodis Roland Strauß Carsten Duch Christos Consoulas Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory. PLoS ONE |
| title | Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory. |
| title_full | Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory. |
| title_fullStr | Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory. |
| title_full_unstemmed | Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory. |
| title_short | Biological aging of two innate behaviors of Drosophila melanogaster: Escape climbing versus courtship learning and memory. |
| title_sort | biological aging of two innate behaviors of drosophila melanogaster escape climbing versus courtship learning and memory |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293252&type=printable |
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