The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD/ULK1 is involved in the formation of diabetic cataracts

The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD/ULK1 is involved in the formation of diabetic cataracts

Abstract Background Cataracts are the leading cause of blindness and a common ocular complication of diabetes. The epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) and altered autophagic activity occur during the development of diabetic cataracts. The disturbed interaction of...

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Bibliographic Details
Main Authors: Jiyuan Ma, Wei Ye, Yunshu Yang, Tong Wu, Yafen Wang, Ji Li, Rui Pei, Mengmei He, Luning Zhang, Jian Zhou
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Medicine
Subjects:
Diabetic cataract
Lens epithelial cells
Autophagy
Epithelial-mesenchymal transition
Notch signaling pathway
AKT/mTOR/ULK1 signaling pathway
Online Access:https://doi.org/10.1186/s10020-022-00540-2

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