ADA as main biochemical marker in patients with tuberculous effusion
Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient bioma...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304722J.pdf |
| _version_ | 1797396425465659392 |
|---|---|
| author | Janković Jelena Ilić Branislav Đurđević Nataša Jandrić Aleksandar |
| author_facet | Janković Jelena Ilić Branislav Đurđević Nataša Jandrić Aleksandar |
| author_sort | Janković Jelena |
| collection | DOAJ |
| description | Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures and pathophysiological biopsy finding from the majority of patients are positive only in less than 10%. Löwenstein culture results need time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) is biomarker with high sensitivity and specificity (more than 90%) and considered as gold standard of biomarkers in the diagnosis of TP. It is very hard to distinguish malignant from TP with lymphocyte predomination, but in patient with malignant pleural effusion the level of ADA is decreased, opposite from TP. ADA in pleural punctate is a fast, simple, efficient and economical way for clarification the etiology of the pleural effusion as tuberculous pleurisy. Also, many studies have proved the role of ADA in the response to treatment for tuberculosis at follow up period. |
| first_indexed | 2024-03-09T00:51:06Z |
| format | Article |
| id | doaj.art-fcb4f9260d3b4b2abdf271e39c2a50e2 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-09T00:51:06Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-fcb4f9260d3b4b2abdf271e39c2a50e22023-12-11T17:15:37ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-0142472272610.5937/jomb0-440181452-82582304722JADA as main biochemical marker in patients with tuberculous effusionJanković Jelena0Ilić Branislav1Đurđević Nataša2Jandrić Aleksandar3University Clinical Center of Serbia, Clinic for Pulmonology, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Pulmonology, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Pulmonology, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Pulmonology, Belgrade, SerbiaTuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because of tuberculous pleurisy is hard to diagnose due to slow course of disease and lack of specificity in symptoms and diagnostic methods. In that reason, we need multidisciplinary approach and efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures and pathophysiological biopsy finding from the majority of patients are positive only in less than 10%. Löwenstein culture results need time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) is biomarker with high sensitivity and specificity (more than 90%) and considered as gold standard of biomarkers in the diagnosis of TP. It is very hard to distinguish malignant from TP with lymphocyte predomination, but in patient with malignant pleural effusion the level of ADA is decreased, opposite from TP. ADA in pleural punctate is a fast, simple, efficient and economical way for clarification the etiology of the pleural effusion as tuberculous pleurisy. Also, many studies have proved the role of ADA in the response to treatment for tuberculosis at follow up period.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304722J.pdfadenosine deaminasebiomarkerspleural effusiontuberculosis |
| spellingShingle | Janković Jelena Ilić Branislav Đurđević Nataša Jandrić Aleksandar ADA as main biochemical marker in patients with tuberculous effusion Journal of Medical Biochemistry adenosine deaminase biomarkers pleural effusion tuberculosis |
| title | ADA as main biochemical marker in patients with tuberculous effusion |
| title_full | ADA as main biochemical marker in patients with tuberculous effusion |
| title_fullStr | ADA as main biochemical marker in patients with tuberculous effusion |
| title_full_unstemmed | ADA as main biochemical marker in patients with tuberculous effusion |
| title_short | ADA as main biochemical marker in patients with tuberculous effusion |
| title_sort | ada as main biochemical marker in patients with tuberculous effusion |
| topic | adenosine deaminase biomarkers pleural effusion tuberculosis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582304722J.pdf |
| work_keys_str_mv | AT jankovicjelena adaasmainbiochemicalmarkerinpatientswithtuberculouseffusion AT ilicbranislav adaasmainbiochemicalmarkerinpatientswithtuberculouseffusion AT đurđevicnatasa adaasmainbiochemicalmarkerinpatientswithtuberculouseffusion AT jandricaleksandar adaasmainbiochemicalmarkerinpatientswithtuberculouseffusion |