Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population
Individuals with psychopathy possess emotional and behavioral abnormalities. Two neural regions, involved in behavioral control and emotion regulation, are often implicated: amygdala and ventromedial prefrontal cortex (VMPFC). Recently, in studies using adult criminal populations, reductions in micr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158215000546 |
| _version_ | 1819029165256474624 |
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| author | Mona Sobhani Laura Baker Bradford Martins Catherine Tuvblad Lisa Aziz-Zadeh |
| author_facet | Mona Sobhani Laura Baker Bradford Martins Catherine Tuvblad Lisa Aziz-Zadeh |
| author_sort | Mona Sobhani |
| collection | DOAJ |
| description | Individuals with psychopathy possess emotional and behavioral abnormalities. Two neural regions, involved in behavioral control and emotion regulation, are often implicated: amygdala and ventromedial prefrontal cortex (VMPFC). Recently, in studies using adult criminal populations, reductions in microstructural integrity of the white matter connections (i.e., uncinate fasciculus (UF)) between these two neural regions have been discovered in criminals with psychopathy, supporting the notion of neural dysfunction in the amygdala–VMPFC circuit. Here, a young adult, community sample is used to assess whether psychopathic traits modulate microstructural integrity of UF, and whether this relationship is dependent upon levels of trait anxiety, which is sometimes used to distinguish subtypes of psychopathy. Results reveal a negative association between psychopathic traits and microstructural integrity of UF, supporting previous findings. However, no moderation of the relationship by trait anxiety was discovered. Findings provide further support for the notion of altered amygdala–VMPFC connectivity in association with higher psychopathic traits. |
| first_indexed | 2024-12-21T06:09:55Z |
| format | Article |
| id | doaj.art-fcb5e9b9555545ce8895eb392b3e5e34 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-21T06:09:55Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-fcb5e9b9555545ce8895eb392b3e5e342022-12-21T19:13:33ZengElsevierNeuroImage: Clinical2213-15822015-01-018C323810.1016/j.nicl.2015.03.012Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community populationMona Sobhani0Laura Baker1Bradford Martins2Catherine Tuvblad3Lisa Aziz-Zadeh4Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USADepartment of Psychology, University of Southern California, Los Angeles, CA, USABrain and Creativity Institute, Los Angeles, CA, USADepartment of Psychology, University of Southern California, Los Angeles, CA, USABrain and Creativity Institute, Los Angeles, CA, USAIndividuals with psychopathy possess emotional and behavioral abnormalities. Two neural regions, involved in behavioral control and emotion regulation, are often implicated: amygdala and ventromedial prefrontal cortex (VMPFC). Recently, in studies using adult criminal populations, reductions in microstructural integrity of the white matter connections (i.e., uncinate fasciculus (UF)) between these two neural regions have been discovered in criminals with psychopathy, supporting the notion of neural dysfunction in the amygdala–VMPFC circuit. Here, a young adult, community sample is used to assess whether psychopathic traits modulate microstructural integrity of UF, and whether this relationship is dependent upon levels of trait anxiety, which is sometimes used to distinguish subtypes of psychopathy. Results reveal a negative association between psychopathic traits and microstructural integrity of UF, supporting previous findings. However, no moderation of the relationship by trait anxiety was discovered. Findings provide further support for the notion of altered amygdala–VMPFC connectivity in association with higher psychopathic traits.http://www.sciencedirect.com/science/article/pii/S2213158215000546Diffusion tensor imagingPsychopathyUncinate fasciculusMicrostructural integrity |
| spellingShingle | Mona Sobhani Laura Baker Bradford Martins Catherine Tuvblad Lisa Aziz-Zadeh Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population NeuroImage: Clinical Diffusion tensor imaging Psychopathy Uncinate fasciculus Microstructural integrity |
| title | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
| title_full | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
| title_fullStr | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
| title_full_unstemmed | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
| title_short | Psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
| title_sort | psychopathic traits modulate microstructural integrity of right uncinate fasciculus in a community population |
| topic | Diffusion tensor imaging Psychopathy Uncinate fasciculus Microstructural integrity |
| url | http://www.sciencedirect.com/science/article/pii/S2213158215000546 |
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