The role of ectonucleotidases CD39 and CD73 and adenosine signalling in solid organ transplantation

The role of ectonucleotidases CD39 and CD73 and adenosine signalling in solid organ transplantation

Extracellular adenosine is a potent immunomodulatory molecule that accumulates in states of inflammation. Nucleotides such as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) are release from injured and necrotic cells and hydrolysed to adenosine monophosphate (AMP) and adenosine by the...

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Bibliographic Details
Main Authors: Veena eRoberts, John eStagg, Karen M Dwyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Immunology
Subjects:
Adenosine
Immunosuppression
B cells
Treg
CD73
CD39
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00064/full

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