Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats
Background: Anogeissus pendula Edgew (Combretacae) is a traditional Indian medicinal plant with antiulcer, anti-inflammatory, anti-hepatoprotective and other pharmacological effects. A. pendula is commonly used by tribal groups to treat gastric disorders, and this may be due to phenolic compounds. P...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031321001093 |
| _version_ | 1818383890057789440 |
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| author | Priyanka Danai Saraswati Patel Varsha Pandey Purendra Singh Govind Yadav Amit Kumar Teena Agarwal |
| author_facet | Priyanka Danai Saraswati Patel Varsha Pandey Purendra Singh Govind Yadav Amit Kumar Teena Agarwal |
| author_sort | Priyanka Danai |
| collection | DOAJ |
| description | Background: Anogeissus pendula Edgew (Combretacae) is a traditional Indian medicinal plant with antiulcer, anti-inflammatory, anti-hepatoprotective and other pharmacological effects. A. pendula is commonly used by tribal groups to treat gastric disorders, and this may be due to phenolic compounds. Purpose: The aim of this study is to determine the antiulcer activity of Anogeissus pendula in pylorus ligated albino Wistar rats, and the biochemical function in ulcer protection via various biochemical studies. Study Design: The study was conducted on albino Wistar rats using a pylorus ligation ulcer model. Ranitidine (20 mg/kg b.w) and APHAE (200 and 400 mg/kg b.w) were given orally to different groups of rats (n = 6), 1 h before pylorus ligation. The studied parameters were the amount of gastric juice, pH, total and free acidity, and ulcer index. The antioxidant parameters like LPO, GSH, CAT, SOD, and total protein were also studied. Results: At doses of 200 and 400 mg/kg, Anogeissus pendula stem hydroalcoholic extract (APHAE) demonstrated substantial inhibition of gastric lesions. In the pretreated animals, there was a decrease in ulcer index (P < 0.001) and a decrease in gastric volume, free and total acidity (P <0.001). The pH of the gastric juice, on the other hand, increased significantly. In the animals given APHAE medications, the protein content was found to be significantly lower (P< 0.001). In the gastric juice of pylorus ligated rats, APHAE pretreatment substantially reduced the rise in SOD, GSH, and CAT accompanied by a decrease in LPO (P< 0.001). Conclusion: The study revealed that Anogeissus pendula hydroalcoholic extract has considerable antioxidant potential. As a result, additional research into the separation and elucidation of individual phytochemicals and their action mechanisms is required. |
| first_indexed | 2024-12-14T03:13:33Z |
| format | Article |
| id | doaj.art-fcb691fa06204be9a88b2ca6734de6ad |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-12-14T03:13:33Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-fcb691fa06204be9a88b2ca6734de6ad2022-12-21T23:19:12ZengElsevierPhytomedicine Plus2667-03132021-11-0114100127Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar ratsPriyanka Danai0Saraswati Patel1Varsha Pandey2Purendra Singh3Govind Yadav4Amit Kumar5Teena Agarwal6Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, India; Corresponding authors.Department of Pharmacy, BanasthaliVidyapith, Rajasthan, IndiaDepartment of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, IndiaDepartment of Chemistry, BanasthaliVidyapith, Rajasthan, IndiaMutagenicity Laboratory, CSIR-Indian Institute of Integrative Medicine, IndiaMutagenicity Laboratory, CSIR-Indian Institute of Integrative Medicine, India; Corresponding authors.Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, IndiaBackground: Anogeissus pendula Edgew (Combretacae) is a traditional Indian medicinal plant with antiulcer, anti-inflammatory, anti-hepatoprotective and other pharmacological effects. A. pendula is commonly used by tribal groups to treat gastric disorders, and this may be due to phenolic compounds. Purpose: The aim of this study is to determine the antiulcer activity of Anogeissus pendula in pylorus ligated albino Wistar rats, and the biochemical function in ulcer protection via various biochemical studies. Study Design: The study was conducted on albino Wistar rats using a pylorus ligation ulcer model. Ranitidine (20 mg/kg b.w) and APHAE (200 and 400 mg/kg b.w) were given orally to different groups of rats (n = 6), 1 h before pylorus ligation. The studied parameters were the amount of gastric juice, pH, total and free acidity, and ulcer index. The antioxidant parameters like LPO, GSH, CAT, SOD, and total protein were also studied. Results: At doses of 200 and 400 mg/kg, Anogeissus pendula stem hydroalcoholic extract (APHAE) demonstrated substantial inhibition of gastric lesions. In the pretreated animals, there was a decrease in ulcer index (P < 0.001) and a decrease in gastric volume, free and total acidity (P <0.001). The pH of the gastric juice, on the other hand, increased significantly. In the animals given APHAE medications, the protein content was found to be significantly lower (P< 0.001). In the gastric juice of pylorus ligated rats, APHAE pretreatment substantially reduced the rise in SOD, GSH, and CAT accompanied by a decrease in LPO (P< 0.001). Conclusion: The study revealed that Anogeissus pendula hydroalcoholic extract has considerable antioxidant potential. As a result, additional research into the separation and elucidation of individual phytochemicals and their action mechanisms is required.http://www.sciencedirect.com/science/article/pii/S2667031321001093Antiulcer-activityAntisecretory parametersH. pyloriNSAIDs, Peptic-ulcers |
| spellingShingle | Priyanka Danai Saraswati Patel Varsha Pandey Purendra Singh Govind Yadav Amit Kumar Teena Agarwal Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats Phytomedicine Plus Antiulcer-activity Antisecretory parameters H. pylori NSAIDs, Peptic-ulcers |
| title | Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats |
| title_full | Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats |
| title_fullStr | Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats |
| title_full_unstemmed | Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats |
| title_short | Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats |
| title_sort | antiulcerogenic activity of anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in albino wistar rats |
| topic | Antiulcer-activity Antisecretory parameters H. pylori NSAIDs, Peptic-ulcers |
| url | http://www.sciencedirect.com/science/article/pii/S2667031321001093 |
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