| Summary: | The aim of this study was establish if the
fructooligosaccharides (FOS) and inulin alone or together
attenuate age related bone loss in skeletally mature female
rats. Forty 10-month old female rats were randomly assigned
to four diet groups for 2 months: control, FOS, inulin and
FOS + inulin. Bone mineral density (BMD) using dualenergy
X-ray absorptiometry (DXA), femur quality using
morphometry and biomechanic properties, biochemical
assays by the determination of serum parathyroid hormone
(PTH), alkaline phosphatase activity (ALP), degradation
products of C-terminal peptides of type I collagen (CTX-I),
osteocalcin (OC), osteoprotegerin (OPG) and nuclear
factor κappa B ligand (RANk-L). The FOS increased hip
axis BMD (0.255 ± 0.005 g/cm2
) and femur neck width
(2.19 ± 0.01 mm) and reduced PTH (4.0 x 10-3 ± 0.0006
µg/L), FOS + inulin increased the femur proportional limit
(87.2 ± 1.0 N) and reduced PTH (2.5 x 10-3 ± 0.0006 µg/L)
and ALP (23.2 ± 5.1 U/L), all the prebiotics reduced OPG
(FOS = 1.1 ± 0.3, inulin = 1.1 ± 0.3, FOS + inulin = 1.4 ±
0.4 µg/L) and RANk-L (FOS = 1.65 x 10-2 ± 0.003, inulin
= 1.78 x 10-2 ± 0.003, FOS + inulin = 2.83 x 10-2 ± 0.006
µg/L ), no prebiotics changed OC and CTX-I. The results
suggested that the consumption of FOS or FOS + inulin
may reduce the bone turnover, however, further studies
about prebiotics and their synergistic effect on age related
bone loss are required.
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