EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS
The aim of this study was establish if the fructooligosaccharides (FOS) and inulin alone or together attenuate age related bone loss in skeletally mature female rats. Forty 10-month old female rats were randomly assigned to four diet groups for 2 months: control, FOS, inulin and FOS + inulin. B...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2012-12-01
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| Series: | Alimentos e Nutrição |
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| Online Access: | http://serv-bib.fcfar.unesp.br/seer/index.php/alimentos/article/view/515/1966 |
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| author | Claudia Cardoso NETTO Vivian Cristine Correia VIEIRA Cinthia Betin CAZARIN Sherry AGELLON Hope WEILER Mario Roberto MARÓSTICA JÚNIOR |
| author_facet | Claudia Cardoso NETTO Vivian Cristine Correia VIEIRA Cinthia Betin CAZARIN Sherry AGELLON Hope WEILER Mario Roberto MARÓSTICA JÚNIOR |
| author_sort | Claudia Cardoso NETTO |
| collection | DOAJ |
| description | The aim of this study was establish if the
fructooligosaccharides (FOS) and inulin alone or together
attenuate age related bone loss in skeletally mature female
rats. Forty 10-month old female rats were randomly assigned
to four diet groups for 2 months: control, FOS, inulin and
FOS + inulin. Bone mineral density (BMD) using dualenergy
X-ray absorptiometry (DXA), femur quality using
morphometry and biomechanic properties, biochemical
assays by the determination of serum parathyroid hormone
(PTH), alkaline phosphatase activity (ALP), degradation
products of C-terminal peptides of type I collagen (CTX-I),
osteocalcin (OC), osteoprotegerin (OPG) and nuclear
factor κappa B ligand (RANk-L). The FOS increased hip
axis BMD (0.255 ± 0.005 g/cm2
) and femur neck width
(2.19 ± 0.01 mm) and reduced PTH (4.0 x 10-3 ± 0.0006
µg/L), FOS + inulin increased the femur proportional limit
(87.2 ± 1.0 N) and reduced PTH (2.5 x 10-3 ± 0.0006 µg/L)
and ALP (23.2 ± 5.1 U/L), all the prebiotics reduced OPG
(FOS = 1.1 ± 0.3, inulin = 1.1 ± 0.3, FOS + inulin = 1.4 ±
0.4 µg/L) and RANk-L (FOS = 1.65 x 10-2 ± 0.003, inulin
= 1.78 x 10-2 ± 0.003, FOS + inulin = 2.83 x 10-2 ± 0.006
µg/L ), no prebiotics changed OC and CTX-I. The results
suggested that the consumption of FOS or FOS + inulin
may reduce the bone turnover, however, further studies
about prebiotics and their synergistic effect on age related
bone loss are required. |
| first_indexed | 2024-12-22T11:00:56Z |
| format | Article |
| id | doaj.art-fcb701c046dd4484baafc40a63413d7f |
| institution | Directory Open Access Journal |
| issn | 0103-4235 |
| language | English |
| last_indexed | 2024-12-22T11:00:56Z |
| publishDate | 2012-12-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Alimentos e Nutrição |
| spelling | doaj.art-fcb701c046dd4484baafc40a63413d7f2022-12-21T18:28:31ZengUniversidade Estadual PaulistaAlimentos e Nutrição0103-42352012-12-01234515520EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATSClaudia Cardoso NETTO0Vivian Cristine Correia VIEIRA1Cinthia Betin CAZARIN2Sherry AGELLON3Hope WEILER4Mario Roberto MARÓSTICA JÚNIOR5University of Campinas – UNICAMP University of Campinas – UNICAMP University of Campinas – UNICAMP University of Campinas – UNICAMP University of Campinas – UNICAMP University of Campinas – UNICAMP The aim of this study was establish if the fructooligosaccharides (FOS) and inulin alone or together attenuate age related bone loss in skeletally mature female rats. Forty 10-month old female rats were randomly assigned to four diet groups for 2 months: control, FOS, inulin and FOS + inulin. Bone mineral density (BMD) using dualenergy X-ray absorptiometry (DXA), femur quality using morphometry and biomechanic properties, biochemical assays by the determination of serum parathyroid hormone (PTH), alkaline phosphatase activity (ALP), degradation products of C-terminal peptides of type I collagen (CTX-I), osteocalcin (OC), osteoprotegerin (OPG) and nuclear factor κappa B ligand (RANk-L). The FOS increased hip axis BMD (0.255 ± 0.005 g/cm2 ) and femur neck width (2.19 ± 0.01 mm) and reduced PTH (4.0 x 10-3 ± 0.0006 µg/L), FOS + inulin increased the femur proportional limit (87.2 ± 1.0 N) and reduced PTH (2.5 x 10-3 ± 0.0006 µg/L) and ALP (23.2 ± 5.1 U/L), all the prebiotics reduced OPG (FOS = 1.1 ± 0.3, inulin = 1.1 ± 0.3, FOS + inulin = 1.4 ± 0.4 µg/L) and RANk-L (FOS = 1.65 x 10-2 ± 0.003, inulin = 1.78 x 10-2 ± 0.003, FOS + inulin = 2.83 x 10-2 ± 0.006 µg/L ), no prebiotics changed OC and CTX-I. The results suggested that the consumption of FOS or FOS + inulin may reduce the bone turnover, however, further studies about prebiotics and their synergistic effect on age related bone loss are required.http://serv-bib.fcfar.unesp.br/seer/index.php/alimentos/article/view/515/1966Agingbone tissueprebioticsosteoporosisrats |
| spellingShingle | Claudia Cardoso NETTO Vivian Cristine Correia VIEIRA Cinthia Betin CAZARIN Sherry AGELLON Hope WEILER Mario Roberto MARÓSTICA JÚNIOR EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS Alimentos e Nutrição Aging bone tissue prebiotics osteoporosis rats |
| title | EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS |
| title_full | EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS |
| title_fullStr | EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS |
| title_full_unstemmed | EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS |
| title_short | EFFECTS OF THE FRUCTOOLIGOSACCHARIDES (FOS) AND INULIN ON BONE METABOLISM OF THE SKELETALLY MATURE FEMALE RATS |
| title_sort | effects of the fructooligosaccharides fos and inulin on bone metabolism of the skeletally mature female rats |
| topic | Aging bone tissue prebiotics osteoporosis rats |
| url | http://serv-bib.fcfar.unesp.br/seer/index.php/alimentos/article/view/515/1966 |
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