IIAEK Targets Intestinal Alkaline Phosphatase (IAP) to Improve Cholesterol Metabolism with a Specific Activation of IAP and Downregulation of ABCA1

IIAEK Targets Intestinal Alkaline Phosphatase (IAP) to Improve Cholesterol Metabolism with a Specific Activation of IAP and Downregulation of ABCA1

IIAEK (Ile-Ile-Ala-Glu-Lys, lactostatin) is a novel cholesterol-lowering pentapeptide derived from bovine milk β-lactoglobulin. However, the molecular mechanisms underlying the IIAEK-mediated suppression of intestinal cholesterol absorption are unknown. Therefore, we evaluated the effects of IIAEK o...

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Bibliographic Details
Main Authors: Asahi Takeuchi, Kentaro Hisamatsu, Natsuki Okumura, Yuki Sugimitsu, Emiko Yanase, Yoshihito Ueno, Satoshi Nagaoka
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Nutrients
Subjects:
IIAEK
alkaline phosphatase
photoaffinity labeling
Caco-2 cells
cholesterol
ABCA1
Online Access:https://www.mdpi.com/2072-6643/12/9/2859

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