Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

A synergistic combination of in vitro electrophysiology and multicompartmental modeling of rat CA1 pyramidal neurons identified TRPM4 channels as major drivers of cholinergic modulation of the firing rate during a triangular current ramp, which emulates the bump in synaptic input received while trav...

Full description

Bibliographic Details
Main Authors: Crescent L Combe, Carol M Upchurch, Carmen C Canavier, Sonia Gasparini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
hippocampus
multicompartmental modeling
patch clamp
nanodomain
nonspecific cation current
neuromodulation
Online Access:https://elifesciences.org/articles/84387

Similar Items

Similar Items