Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness
Objective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal serum concentrations of free thyroxine, suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children. Controversy remains, whether a thyroid dysfunction related to obesity...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2018-12-01
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| Series: | Journal of Ultrasonography |
| Subjects: | |
| Online Access: | http://jultrason.pl/index.php/issues/volume-18-no-75/serum-tsh-level-in-obese-children-and-its-correlations-with-atherogenic-lipid-indicators-and-carotid-intima-media-thickness?aid=675 |
| Summary: | Objective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal
serum concentrations of free thyroxine, suggesting subclinical hypothyroidism, is the most
common hormonal abnormality in obese children. Controversy remains, whether a thyroid
dysfunction related to obesity has an influence on the cardiovascular risk factors. The aim of
the study was to assess correlation between thyroid-stimulating hormone and free thyroxine
and chosen atherogenic lipid indicators, and carotid intima media thickness in obese children and adolescents. Methods: A study group consisted of 110 obese children (11.5 ± 2.9
years) and 38 healthy children (13.4 ± 2.6 years). Obesity was defined using International
Obesity Task Force criteria. In each patient anthropometric measurements, thyroid-stimulating hormone, free thyroxine, a lipid profile were evaluated. Carotid intima-media thickness
was measured in 74 obese children and 28 lean children. The resulting data were used to
calculate indicators of atherogenesis: total cholesterol to HDL cholesterol ratio; triglycerides to HDL cholesterol ratio and LDL cholesterol to HDL cholesterol ratio. Results: Obese
children had higher mean serum thyroid-stimulating hormone levels compared to their lean
peers and an adverse atherogenic lipid profile. Serum free thyroxine concentrations were
comparable between the groups. Serum thyroid-stimulating hormone values correlated with
total cholesterol to HDL cholesterol ratio; triglycerides to HDL cholesterol ratio, LDL cholesterol to HDL cholesterol ratio, and intima-media thickness. In a multivariate regression
analysis, thyroid-stimulating hormone weakly correlated only with intima-media thickness
after adjustment for age, gender and Body Mass Index (β = 0.249, p = 0.04). This relationship weakened after considering a lipid profile (β = 0.242, p = 0.058). No relationship was
found for free thyroxine. Conclusion: Serum level of thyroid-stimulating hormone in obese
children did not seem to impact atherogenic lipid indicators and carotid intima-media thickness. Therefore, an adverse lipid profile should still be considered the main risk factor for
development of cardiovascular diseases in obese children. |
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| ISSN: | 2084-8404 2451-070X |