Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness
Objective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal serum concentrations of free thyroxine, suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children. Controversy remains, whether a thyroid dysfunction related to obesity...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-12-01
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| Series: | Journal of Ultrasonography |
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| Online Access: | http://jultrason.pl/index.php/issues/volume-18-no-75/serum-tsh-level-in-obese-children-and-its-correlations-with-atherogenic-lipid-indicators-and-carotid-intima-media-thickness?aid=675 |
| _version_ | 1818472257357348864 |
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| author | Małgorzata Rumińska Ewelina Witkowska-Sędek Anna Majcher Michał Brzewski Monika Krawczyk Beata Pyrżak |
| author_facet | Małgorzata Rumińska Ewelina Witkowska-Sędek Anna Majcher Michał Brzewski Monika Krawczyk Beata Pyrżak |
| author_sort | Małgorzata Rumińska |
| collection | DOAJ |
| description | Objective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal
serum concentrations of free thyroxine, suggesting subclinical hypothyroidism, is the most
common hormonal abnormality in obese children. Controversy remains, whether a thyroid
dysfunction related to obesity has an influence on the cardiovascular risk factors. The aim of
the study was to assess correlation between thyroid-stimulating hormone and free thyroxine
and chosen atherogenic lipid indicators, and carotid intima media thickness in obese children and adolescents. Methods: A study group consisted of 110 obese children (11.5 ± 2.9
years) and 38 healthy children (13.4 ± 2.6 years). Obesity was defined using International
Obesity Task Force criteria. In each patient anthropometric measurements, thyroid-stimulating hormone, free thyroxine, a lipid profile were evaluated. Carotid intima-media thickness
was measured in 74 obese children and 28 lean children. The resulting data were used to
calculate indicators of atherogenesis: total cholesterol to HDL cholesterol ratio; triglycerides to HDL cholesterol ratio and LDL cholesterol to HDL cholesterol ratio. Results: Obese
children had higher mean serum thyroid-stimulating hormone levels compared to their lean
peers and an adverse atherogenic lipid profile. Serum free thyroxine concentrations were
comparable between the groups. Serum thyroid-stimulating hormone values correlated with
total cholesterol to HDL cholesterol ratio; triglycerides to HDL cholesterol ratio, LDL cholesterol to HDL cholesterol ratio, and intima-media thickness. In a multivariate regression
analysis, thyroid-stimulating hormone weakly correlated only with intima-media thickness
after adjustment for age, gender and Body Mass Index (β = 0.249, p = 0.04). This relationship weakened after considering a lipid profile (β = 0.242, p = 0.058). No relationship was
found for free thyroxine. Conclusion: Serum level of thyroid-stimulating hormone in obese
children did not seem to impact atherogenic lipid indicators and carotid intima-media thickness. Therefore, an adverse lipid profile should still be considered the main risk factor for
development of cardiovascular diseases in obese children. |
| first_indexed | 2024-04-14T04:04:21Z |
| format | Article |
| id | doaj.art-fcbb1d47fbc74008817a12cbf5c0c4c0 |
| institution | Directory Open Access Journal |
| issn | 2084-8404 2451-070X |
| language | English |
| last_indexed | 2024-04-14T04:04:21Z |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Ultrasonography |
| spelling | doaj.art-fcbb1d47fbc74008817a12cbf5c0c4c02022-12-22T02:13:25ZengSciendoJournal of Ultrasonography2084-84042451-070X2018-12-01187529630110.15557/JoU.2018.0043Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thicknessMałgorzata Rumińska0Ewelina Witkowska-Sędek1Anna Majcher2Michał Brzewski3Monika Krawczyk4Beata Pyrżak5Department of Pediatrics and Endocrinology, Medical University of Warsaw, PolandDepartment of Pediatrics and Endocrinology, Medical University of Warsaw, PolandDepartment of Pediatrics and Endocrinology, Medical University of Warsaw, PolandDepartment of Pediatric Radiology, Medical University of Warsaw, PolandDepartment of Pediatrics and Endocrinology, Medical University of Warsaw, PolandDepartment of Pediatrics and Endocrinology, Medical University of Warsaw, PolandObjective: Moderately elevated level of thyroid-stimulating hormone accompanied by normal serum concentrations of free thyroxine, suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children. Controversy remains, whether a thyroid dysfunction related to obesity has an influence on the cardiovascular risk factors. The aim of the study was to assess correlation between thyroid-stimulating hormone and free thyroxine and chosen atherogenic lipid indicators, and carotid intima media thickness in obese children and adolescents. Methods: A study group consisted of 110 obese children (11.5 ± 2.9 years) and 38 healthy children (13.4 ± 2.6 years). Obesity was defined using International Obesity Task Force criteria. In each patient anthropometric measurements, thyroid-stimulating hormone, free thyroxine, a lipid profile were evaluated. Carotid intima-media thickness was measured in 74 obese children and 28 lean children. The resulting data were used to calculate indicators of atherogenesis: total cholesterol to HDL cholesterol ratio; triglycerides to HDL cholesterol ratio and LDL cholesterol to HDL cholesterol ratio. Results: Obese children had higher mean serum thyroid-stimulating hormone levels compared to their lean peers and an adverse atherogenic lipid profile. Serum free thyroxine concentrations were comparable between the groups. Serum thyroid-stimulating hormone values correlated with total cholesterol to HDL cholesterol ratio; triglycerides to HDL cholesterol ratio, LDL cholesterol to HDL cholesterol ratio, and intima-media thickness. In a multivariate regression analysis, thyroid-stimulating hormone weakly correlated only with intima-media thickness after adjustment for age, gender and Body Mass Index (β = 0.249, p = 0.04). This relationship weakened after considering a lipid profile (β = 0.242, p = 0.058). No relationship was found for free thyroxine. Conclusion: Serum level of thyroid-stimulating hormone in obese children did not seem to impact atherogenic lipid indicators and carotid intima-media thickness. Therefore, an adverse lipid profile should still be considered the main risk factor for development of cardiovascular diseases in obese children.http://jultrason.pl/index.php/issues/volume-18-no-75/serum-tsh-level-in-obese-children-and-its-correlations-with-atherogenic-lipid-indicators-and-carotid-intima-media-thickness?aid=675TSHcarotid IMTobesitychildren |
| spellingShingle | Małgorzata Rumińska Ewelina Witkowska-Sędek Anna Majcher Michał Brzewski Monika Krawczyk Beata Pyrżak Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness Journal of Ultrasonography TSH carotid IMT obesity children |
| title | Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness |
| title_full | Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness |
| title_fullStr | Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness |
| title_full_unstemmed | Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness |
| title_short | Serum TSH level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness |
| title_sort | serum tsh level in obese children and its correlations with atherogenic lipid indicators and carotid intima media thickness |
| topic | TSH carotid IMT obesity children |
| url | http://jultrason.pl/index.php/issues/volume-18-no-75/serum-tsh-level-in-obese-children-and-its-correlations-with-atherogenic-lipid-indicators-and-carotid-intima-media-thickness?aid=675 |
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