Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study
We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this niclosamide ASD formulation increased the apparent drug solubility about 60-fold relative to the crystalline material due to...
| Main Authors: | , , |
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| 格式: | 文件 |
| 语言: | English |
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MDPI AG
2021-01-01
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| 丛编: | Pharmaceutics |
| 主题: | |
| 在线阅读: | https://www.mdpi.com/1999-4923/13/1/97 |