Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study

Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study

We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this niclosamide ASD formulation increased the apparent drug solubility about 60-fold relative to the crystalline material due to...

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Manylion Llyfryddiaeth
Prif Awduron:	Miguel O. Jara, Zachary N. Warnken, Robert O. Williams
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	MDPI AG 2021-01-01
Cyfres:	Pharmaceutics
Pynciau:	hot-melt extrusion amorphous solid dispersions nanoparticles niclosamide
Mynediad Ar-lein:	https://www.mdpi.com/1999-4923/13/1/97

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