Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment
Abstract The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease. We conducted a cohort study based on population of women < ...
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42583-3 |
| _version_ | 1797559804110045184 |
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| author | Laura Miquel Julie Liotta Alice Hours Pauline Bottin Pierre Castel Jeanne Perrin Catherine Guillemain Blandine Courbiere |
| author_facet | Laura Miquel Julie Liotta Alice Hours Pauline Bottin Pierre Castel Jeanne Perrin Catherine Guillemain Blandine Courbiere |
| author_sort | Laura Miquel |
| collection | DOAJ |
| description | Abstract The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease. We conducted a cohort study based on population of women < 40 years of age with diminished ovarian reserve caused by fertility-impairing treatment (n = 129). Three groups of women were compared according to the type of initial disease: hematological malignancies, solid tumors, and benign diseases. The primary endpoint was the number of metaphase II oocytes collected per woman. We studied the cumulative live-birth rate per cycle with fertilized metaphase II oocyte, for women who wanted to conceive. We studied 245 delayed controlled ovarian stimulation cycles in 129 women: 201 for fertility preservation and 44 for in vitro fertilization and fresh embryo transfers. The number of metaphase II oocytes collected per woman after banking was similar in the three groups, with a mean of 10.7 ± 4.6, 12.3 ± 9.1, and 10.1 ± 7.6 metaphase II oocytes (p = 0.46), respectively. In the subgroup of women who wanted to conceive, the cumulative live birth rate per woman was 38%, with 8 live births for these 21 women. After fertility-impairing treatment, practitioners should discuss a fertility preservation procedure for banking metaphase II oocytes. |
| first_indexed | 2024-03-10T17:50:27Z |
| format | Article |
| id | doaj.art-fcbc68b307a94676a12e54273a0a83db |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:50:27Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fcbc68b307a94676a12e54273a0a83db2023-11-20T09:24:22ZengNature PortfolioScientific Reports2045-23222023-09-011311810.1038/s41598-023-42583-3Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatmentLaura Miquel0Julie Liotta1Alice Hours2Pauline Bottin3Pierre Castel4Jeanne Perrin5Catherine Guillemain6Blandine Courbiere7Department of Obstetrics, Gynecology and Reproductive Medicine, Pôle femmes parents enfants, AP-HM, La Conception University HospitalDepartment of Obstetrics, Gynecology and Reproductive Medicine, Pôle femmes parents enfants, AP-HM, La Conception University HospitalDepartment of Obstetrics, Gynecology and Reproductive Medicine, Pôle femmes parents enfants, AP-HM, La Conception University HospitalDepartment of Obstetrics, Gynecology and Reproductive Medicine, Pôle femmes parents enfants, AP-HM, La Conception University HospitalDepartment of Obstetrics, Gynecology and Reproductive Medicine, Pôle femmes parents enfants, AP-HM, La Conception University HospitalAix Marseille Univ, CNRS, IRD, Avignon Université, IMBEAix Marseille Univ, INSERM, MMG, UMR_S 1251Aix Marseille Univ, CNRS, IRD, Avignon Université, IMBEAbstract The aim of our study was to evaluate the feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation after fertility-impairing treatment regardless of the initial disease. We conducted a cohort study based on population of women < 40 years of age with diminished ovarian reserve caused by fertility-impairing treatment (n = 129). Three groups of women were compared according to the type of initial disease: hematological malignancies, solid tumors, and benign diseases. The primary endpoint was the number of metaphase II oocytes collected per woman. We studied the cumulative live-birth rate per cycle with fertilized metaphase II oocyte, for women who wanted to conceive. We studied 245 delayed controlled ovarian stimulation cycles in 129 women: 201 for fertility preservation and 44 for in vitro fertilization and fresh embryo transfers. The number of metaphase II oocytes collected per woman after banking was similar in the three groups, with a mean of 10.7 ± 4.6, 12.3 ± 9.1, and 10.1 ± 7.6 metaphase II oocytes (p = 0.46), respectively. In the subgroup of women who wanted to conceive, the cumulative live birth rate per woman was 38%, with 8 live births for these 21 women. After fertility-impairing treatment, practitioners should discuss a fertility preservation procedure for banking metaphase II oocytes.https://doi.org/10.1038/s41598-023-42583-3 |
| spellingShingle | Laura Miquel Julie Liotta Alice Hours Pauline Bottin Pierre Castel Jeanne Perrin Catherine Guillemain Blandine Courbiere Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment Scientific Reports |
| title | Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment |
| title_full | Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment |
| title_fullStr | Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment |
| title_full_unstemmed | Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment |
| title_short | Feasibility and efficiency of delayed ovarian stimulation and metaphase II oocyte banking for fertility preservation and childbearing desire after fertility-impairing treatment |
| title_sort | feasibility and efficiency of delayed ovarian stimulation and metaphase ii oocyte banking for fertility preservation and childbearing desire after fertility impairing treatment |
| url | https://doi.org/10.1038/s41598-023-42583-3 |
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