The microbiome of captive hamadryas baboons
Abstract Background The hamadryas baboon (Papio hamadryas) is a highly social primate that lives in complex multilevel societies exhibiting a wide range of group behaviors akin to humans. In contrast to the widely studied human microbiome, there is a paucity of information on the host-associated mic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Animal Microbiome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42523-020-00040-w |
| _version_ | 1831839637158494208 |
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| author | Xuanji Li Urvish Trivedi Asker Daniel Brejnrod Gisle Vestergaard Martin Steen Mortensen Mads Frost Bertelsen Søren Johannes Sørensen |
| author_facet | Xuanji Li Urvish Trivedi Asker Daniel Brejnrod Gisle Vestergaard Martin Steen Mortensen Mads Frost Bertelsen Søren Johannes Sørensen |
| author_sort | Xuanji Li |
| collection | DOAJ |
| description | Abstract Background The hamadryas baboon (Papio hamadryas) is a highly social primate that lives in complex multilevel societies exhibiting a wide range of group behaviors akin to humans. In contrast to the widely studied human microbiome, there is a paucity of information on the host-associated microbiomes of nonhuman primates (NHPs). Here, our goal was to understand the microbial composition throughout different body sites of cohabiting baboons. Results We analyzed 170 oral, oropharyngeal, cervical, uterine, vaginal, nasal and rectal samples from 16 hamadryas baboons via 16S rRNA gene sequencing. Additionally, raw Miseq sequencing data from 1041 comparable publicly available samples from the human oral cavity, gut and vagina were reanalyzed using the same pipeline. We compared the baboon and human microbiome of the oral cavity, gut and vagina, showing that the baboon microbiome is distinct from the human. Baboon cohabitants share similar microbial profiles in their cervix, uterus, vagina, and gut. The oral cavity, gut and vagina shared more bacterial amplicon sequence variants (ASVs) in group living baboons than in humans. The shared ASVs had significantly positive correlations between most body sites, suggesting a potential bacterial exchange throughout the body. No significant differences in gut microbiome composition were detected within the maternity line and between maternity lines, suggesting that the offspring gut microbiota is shaped primarily through bacterial exchange among cohabitants. Finally, Lactobacillus was not so predominant in baboon vagina as in the human vagina but was the most abundant genus in the baboon gut. Conclusions This study is the first to provide comprehensive analyses of the baboon microbiota across different body sites. We contrast this to human body sites and find substantially different microbiomes. This group of cohabitating baboons generally showed higher microbial diversity and remarkable similarities between body sites than were observed in humans. These data and findings from one group of baboons can form the basis of future microbiome studies in baboons and be used as a reference in research where the microbiome is expected to impact human modeling with baboons. |
| first_indexed | 2024-12-23T05:55:46Z |
| format | Article |
| id | doaj.art-fcc0f076e2264495977bca0fd4c663b4 |
| institution | Directory Open Access Journal |
| issn | 2524-4671 |
| language | English |
| last_indexed | 2024-12-23T05:55:46Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Animal Microbiome |
| spelling | doaj.art-fcc0f076e2264495977bca0fd4c663b42022-12-21T17:57:49ZengBMCAnimal Microbiome2524-46712020-07-012111010.1186/s42523-020-00040-wThe microbiome of captive hamadryas baboonsXuanji Li0Urvish Trivedi1Asker Daniel Brejnrod2Gisle Vestergaard3Martin Steen Mortensen4Mads Frost Bertelsen5Søren Johannes Sørensen6Section of Microbiology, Department of Biology, University of CopenhagenSection of Microbiology, Department of Biology, University of CopenhagenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of CopenhagenSection of Microbiology, Department of Biology, University of CopenhagenSection of Microbiology, Department of Biology, University of CopenhagenCenter for Zoo and Wild Animal HealthSection of Microbiology, Department of Biology, University of CopenhagenAbstract Background The hamadryas baboon (Papio hamadryas) is a highly social primate that lives in complex multilevel societies exhibiting a wide range of group behaviors akin to humans. In contrast to the widely studied human microbiome, there is a paucity of information on the host-associated microbiomes of nonhuman primates (NHPs). Here, our goal was to understand the microbial composition throughout different body sites of cohabiting baboons. Results We analyzed 170 oral, oropharyngeal, cervical, uterine, vaginal, nasal and rectal samples from 16 hamadryas baboons via 16S rRNA gene sequencing. Additionally, raw Miseq sequencing data from 1041 comparable publicly available samples from the human oral cavity, gut and vagina were reanalyzed using the same pipeline. We compared the baboon and human microbiome of the oral cavity, gut and vagina, showing that the baboon microbiome is distinct from the human. Baboon cohabitants share similar microbial profiles in their cervix, uterus, vagina, and gut. The oral cavity, gut and vagina shared more bacterial amplicon sequence variants (ASVs) in group living baboons than in humans. The shared ASVs had significantly positive correlations between most body sites, suggesting a potential bacterial exchange throughout the body. No significant differences in gut microbiome composition were detected within the maternity line and between maternity lines, suggesting that the offspring gut microbiota is shaped primarily through bacterial exchange among cohabitants. Finally, Lactobacillus was not so predominant in baboon vagina as in the human vagina but was the most abundant genus in the baboon gut. Conclusions This study is the first to provide comprehensive analyses of the baboon microbiota across different body sites. We contrast this to human body sites and find substantially different microbiomes. This group of cohabitating baboons generally showed higher microbial diversity and remarkable similarities between body sites than were observed in humans. These data and findings from one group of baboons can form the basis of future microbiome studies in baboons and be used as a reference in research where the microbiome is expected to impact human modeling with baboons.http://link.springer.com/article/10.1186/s42523-020-00040-wBaboonGroup livingBody habitatMicrobiotaBeneficial bacteriaHealth |
| spellingShingle | Xuanji Li Urvish Trivedi Asker Daniel Brejnrod Gisle Vestergaard Martin Steen Mortensen Mads Frost Bertelsen Søren Johannes Sørensen The microbiome of captive hamadryas baboons Animal Microbiome Baboon Group living Body habitat Microbiota Beneficial bacteria Health |
| title | The microbiome of captive hamadryas baboons |
| title_full | The microbiome of captive hamadryas baboons |
| title_fullStr | The microbiome of captive hamadryas baboons |
| title_full_unstemmed | The microbiome of captive hamadryas baboons |
| title_short | The microbiome of captive hamadryas baboons |
| title_sort | microbiome of captive hamadryas baboons |
| topic | Baboon Group living Body habitat Microbiota Beneficial bacteria Health |
| url | http://link.springer.com/article/10.1186/s42523-020-00040-w |
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