Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life

Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life

Background: The amyloid cascade hypothesis characterizes the stereotyped progression of pathological changes in Alzheimer's disease (AD) beginning with beta amyloid deposition, but does not address the reasons for amyloid deposition. Brain areas with relatively higher neuronal activity, metabol...

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Bibliographic Details
Main Authors: Irene B. Meier, Patrick J. Lao, Anton Gietl, Robert S. Vorburger, José Gutierrez, Christopher M. Holland, Charles R.G. Guttmann, Dominik S. Meier, Alfred Buck, Roger M. Nitsch, Christoph Hock, Paul G. Unschuld, Adam M. Brickman
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cerebral Circulation - Cognition and Behavior
Subjects:
Cerebral perfusion
amyloid
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2666245020300015

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