The Antiproliferative and Proapoptotic Effects of Cucurbitacin B on BPH-1 Cells via the p53/MDM2 Axis

The Antiproliferative and Proapoptotic Effects of Cucurbitacin B on BPH-1 Cells via the p53/MDM2 Axis

Cucurbitacin B (Cu B), a triterpenoid compound, has anti-inflammatory and antioxidant activities. Most studies only focus on the hepatoprotective activity of Cu B, and little effort has been geared toward exploring the effect of Cu B on the prostate. Our study identified that Cu B inhibited the prol...

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Bibliographic Details
Main Authors: Ping Zhou, Sisi Huang, Congcong Shao, Dongyan Huang, Yingyi Hu, Xin Su, Rongfu Yang, Juan Jiang, Jianhui Wu
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
triterpenoid compound
cucurbitacin B
prostatic hyperplasia
p53 signaling pathway
Online Access:https://www.mdpi.com/1422-0067/25/1/442

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