Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis
<p>The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups:</p><p>Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis.</p><p>Group 3 - 50 rats with simulat...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2019-12-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/30459 |
| _version_ | 1818738776865767424 |
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| author | I. V. Savytskyi S. V. Tsypoviaz R. G. Lenik O. V. Bilash R. H. Zashchuk I. V. Miastkivska |
| author_facet | I. V. Savytskyi S. V. Tsypoviaz R. G. Lenik O. V. Bilash R. H. Zashchuk I. V. Miastkivska |
| author_sort | I. V. Savytskyi |
| collection | DOAJ |
| description | <p>The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups:</p><p>Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis.</p><p>Group 3 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction and debridement by chlorhexidine solution. Group 4 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction, chlorhexidine debridement and endothelial dysfunction correction with the use of a nitric oxide donor.Fecal peritonitis was modeled using injection of 10% fecal suspension in a dose of 0.5 ml per100 gof animal weight in the abdominal cavity of laboratory animals by puncture method (Lazarenko V.A., et al., 2016, patent No. 233826).</p><p>The following results were obtained.</p><p>Histologically confirmed the development of experimental peritonitis in all groups of the experiment. In the group №2 on the third day the deterioration of the studied structures was established. In the group in which the experimental peritonitis was corrected by antibiotic therapy and chlorhexidine remediation, the effectiveness of the correction was morphologically proven. In group 4, macroscopic and microscopic examinations of the intestine, liver, and abdomen did not reveal significant differences from the histological picture we observed in rats of the intact group.</p> |
| first_indexed | 2024-12-18T01:14:19Z |
| format | Article |
| id | doaj.art-fcc4aeb28ccb48bbb72e534920b79645 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-18T01:14:19Z |
| publishDate | 2019-12-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-fcc4aeb28ccb48bbb72e534920b796452022-12-21T21:26:00ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-12-0191228229710.12775/JEHS.2019.09.12.02924686Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitisI. V. Savytskyi0S. V. Tsypoviaz1R. G. Lenik2O. V. Bilash3R. H. Zashchuk4I. V. Miastkivska5Odessa National Medical UniversityOdessa National Medical UniversityState Enterprise Ukrainian Institute for Medicine of Transport of the Ministry of Health of UkraineOdessa National Medical UniversityOdessa National Medical UniversityOdessa National Medical University<p>The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups:</p><p>Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis.</p><p>Group 3 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction and debridement by chlorhexidine solution. Group 4 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction, chlorhexidine debridement and endothelial dysfunction correction with the use of a nitric oxide donor.Fecal peritonitis was modeled using injection of 10% fecal suspension in a dose of 0.5 ml per100 gof animal weight in the abdominal cavity of laboratory animals by puncture method (Lazarenko V.A., et al., 2016, patent No. 233826).</p><p>The following results were obtained.</p><p>Histologically confirmed the development of experimental peritonitis in all groups of the experiment. In the group №2 on the third day the deterioration of the studied structures was established. In the group in which the experimental peritonitis was corrected by antibiotic therapy and chlorhexidine remediation, the effectiveness of the correction was morphologically proven. In group 4, macroscopic and microscopic examinations of the intestine, liver, and abdomen did not reveal significant differences from the histological picture we observed in rats of the intact group.</p>https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/30459peritonitisexperimental modelhistological examinationcorrectionl-arginin |
| spellingShingle | I. V. Savytskyi S. V. Tsypoviaz R. G. Lenik O. V. Bilash R. H. Zashchuk I. V. Miastkivska Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis Journal of Education, Health and Sport peritonitis experimental model histological examination correction l-arginin |
| title | Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis |
| title_full | Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis |
| title_fullStr | Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis |
| title_full_unstemmed | Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis |
| title_short | Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis |
| title_sort | research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis |
| topic | peritonitis experimental model histological examination correction l-arginin |
| url | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/30459 |
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