Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis
Objective: 18F-Fluorocholine (18FCH) PET/CT has high sensitivity for parathyroid adenoma detection and can reliably exclude malignancy in thyroid nodules with indeterminate cytology. Data regarding 18FCH uptake in chronic autoimmune thyroiditis (CAT) are scarce. We aimed to assess thyroid 18FCH upta...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-01-01
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| Series: | European Thyroid Journal |
| Subjects: | |
| Online Access: | https://etj.bioscientifica.com/view/journals/etj/11/3/ETJ-22-0025.xml |
| _version_ | 1797955035659763712 |
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| author | Renaud Ciappuccini Virginie Saguet-Rysanek Marine Dorbeau Justine Lequesne Camille Linard Sophie Lefevre-Arbogast Bénédicte Clarisse Stéphane Bardet |
| author_facet | Renaud Ciappuccini Virginie Saguet-Rysanek Marine Dorbeau Justine Lequesne Camille Linard Sophie Lefevre-Arbogast Bénédicte Clarisse Stéphane Bardet |
| author_sort | Renaud Ciappuccini |
| collection | DOAJ |
| description | Objective: 18F-Fluorocholine (18FCH) PET/CT has high sensitivity for parathyroid adenoma detection and can reliably exclude malignancy in thyroid nodules with indeterminate cytology. Data regarding 18FCH uptake in chronic autoimmune thyroiditis (CAT) are scarce. We aimed to assess thyroid 18FCH uptake in CAT with biological and histological correlation.
Methods: This is an ancillary study from the Chocolate trial (NCT02784223) that prospectively enrolled 107 patients planned for thyroid surgery. 18FCH PET/CT acquisitions were performed 20 and 60 min after injection. 18FCH uptake in the thyroid gland was assessed by measuring maximum (SUVmax) and mean (SUVmean) standardized uptake values. Thyrotropin, free thyroxine (FT4), thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies were collected. The intensity of thyroiditis and the degree of fibrosis were assessed on pathology.
Results: CAT was evidenced in 19/107 (18%) patients. Of these, 13 (68%) displayed an increased and diffuse 18FCH thyroid uptake. This uptake pattern was not observed in patients without CAT. SUVmax and SUVmean were higher in patients with CAT than in those without (P < 0.001). At both acquisition times, SUVmax showed a monotonic relationship with the intensity of thyroiditis (Spearman ρ = 0.44 and 0.51, respectively, P < 0.001) and with the degree of fibrosis (Spearman ρ = 0.55 and 0.62, respectively, P < 0.001). SUVmax showed a linear relationship with TPOAb titers at 20 min (Pearson r = 0.54, P < 0.05; Spearman ρ = 0.59, P = 0.03).
Conclusions: More than two-thirds of the patients with CAT present high and diffuse thyroid 18FCH uptake. This uptake pattern is highly specific to CAT and is correlated with pathology and TPOAb titers. |
| first_indexed | 2024-04-10T23:28:02Z |
| format | Article |
| id | doaj.art-fcc797bc4a0244f2bc9e668e87ecb013 |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-04-10T23:28:02Z |
| publishDate | 2023-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-fcc797bc4a0244f2bc9e668e87ecb0132023-01-12T11:52:02ZengBioscientificaEuropean Thyroid Journal2235-08022023-01-0111318https://doi.org/10.1530/ETJ-22-0025Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditisRenaud Ciappuccini0Virginie Saguet-Rysanek1Marine Dorbeau2Justine Lequesne3Camille Linard4Sophie Lefevre-Arbogast5Bénédicte Clarisse6Stéphane Bardet7Department of Nuclear Medicine and Thyroid Unit, François Baclesse Cancer Centre, Caen, France; INSERM 1086 ANTICIPE, Caen University, Caen, France Department of Pathology, François Baclesse Cancer Centre, Caen, FranceDepartment of Pathology, François Baclesse Cancer Centre, Caen, FranceDepartment of Clinical Research, François Baclesse Cancer Centre, Caen, FranceDepartment of Pathology, François Baclesse Cancer Centre, Caen, FranceDepartment of Clinical Research, François Baclesse Cancer Centre, Caen, FranceDepartment of Clinical Research, François Baclesse Cancer Centre, Caen, FranceDepartment of Nuclear Medicine and Thyroid Unit, François Baclesse Cancer Centre, Caen, FranceObjective: 18F-Fluorocholine (18FCH) PET/CT has high sensitivity for parathyroid adenoma detection and can reliably exclude malignancy in thyroid nodules with indeterminate cytology. Data regarding 18FCH uptake in chronic autoimmune thyroiditis (CAT) are scarce. We aimed to assess thyroid 18FCH uptake in CAT with biological and histological correlation. Methods: This is an ancillary study from the Chocolate trial (NCT02784223) that prospectively enrolled 107 patients planned for thyroid surgery. 18FCH PET/CT acquisitions were performed 20 and 60 min after injection. 18FCH uptake in the thyroid gland was assessed by measuring maximum (SUVmax) and mean (SUVmean) standardized uptake values. Thyrotropin, free thyroxine (FT4), thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies were collected. The intensity of thyroiditis and the degree of fibrosis were assessed on pathology. Results: CAT was evidenced in 19/107 (18%) patients. Of these, 13 (68%) displayed an increased and diffuse 18FCH thyroid uptake. This uptake pattern was not observed in patients without CAT. SUVmax and SUVmean were higher in patients with CAT than in those without (P < 0.001). At both acquisition times, SUVmax showed a monotonic relationship with the intensity of thyroiditis (Spearman ρ = 0.44 and 0.51, respectively, P < 0.001) and with the degree of fibrosis (Spearman ρ = 0.55 and 0.62, respectively, P < 0.001). SUVmax showed a linear relationship with TPOAb titers at 20 min (Pearson r = 0.54, P < 0.05; Spearman ρ = 0.59, P = 0.03). Conclusions: More than two-thirds of the patients with CAT present high and diffuse thyroid 18FCH uptake. This uptake pattern is highly specific to CAT and is correlated with pathology and TPOAb titers.https://etj.bioscientifica.com/view/journals/etj/11/3/ETJ-22-0025.xml18-fluorocholine pet/ct18fch pet/ctcholinechronic autoimmune thyroiditisdiffuse thyroid uptakediffuse 18fch uptakethyroid imaging |
| spellingShingle | Renaud Ciappuccini Virginie Saguet-Rysanek Marine Dorbeau Justine Lequesne Camille Linard Sophie Lefevre-Arbogast Bénédicte Clarisse Stéphane Bardet Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis European Thyroid Journal 18-fluorocholine pet/ct 18fch pet/ct choline chronic autoimmune thyroiditis diffuse thyroid uptake diffuse 18fch uptake thyroid imaging |
| title | Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis |
| title_full | Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis |
| title_fullStr | Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis |
| title_full_unstemmed | Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis |
| title_short | Thyroid 18F-fluorocholine uptake in patients with chronic autoimmune thyroiditis |
| title_sort | thyroid 18f fluorocholine uptake in patients with chronic autoimmune thyroiditis |
| topic | 18-fluorocholine pet/ct 18fch pet/ct choline chronic autoimmune thyroiditis diffuse thyroid uptake diffuse 18fch uptake thyroid imaging |
| url | https://etj.bioscientifica.com/view/journals/etj/11/3/ETJ-22-0025.xml |
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