Biodegradable Polymer Electrospinning for Tendon Repairment
With the degradation after aging and the destruction of high-intensity exercise, the frequency of tendon injury is also increasing, which will lead to serious pain and disability. Due to the structural specificity of the tendon tissue, the traditional treatment of tendon injury repair has certain li...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/15/6/1566 |
| _version_ | 1797609314929606656 |
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| author | Yiming Zhang Yueguang Xue Yan Ren Xin Li Ying Liu |
| author_facet | Yiming Zhang Yueguang Xue Yan Ren Xin Li Ying Liu |
| author_sort | Yiming Zhang |
| collection | DOAJ |
| description | With the degradation after aging and the destruction of high-intensity exercise, the frequency of tendon injury is also increasing, which will lead to serious pain and disability. Due to the structural specificity of the tendon tissue, the traditional treatment of tendon injury repair has certain limitations. Biodegradable polymer electrospinning technology with good biocompatibility and degradability can effectively repair tendons, and its mechanical properties can be achieved by adjusting the fiber diameter and fiber spacing. Here, this review first briefly introduces the structure and function of the tendon and the repair process after injury. Then, different kinds of biodegradable natural polymers for tendon repair are summarized. Then, the advantages and disadvantages of three-dimensional (3D) electrospun products in tendon repair and regeneration are summarized, as well as the optimization of electrospun fiber scaffolds with different bioactive materials and the latest application in tendon regeneration engineering. Bioactive molecules can optimize the structure of these products and improve their repair performance. Importantly, we discuss the application of the 3D electrospinning scaffold’s superior structure in different stages of tendon repair. Meanwhile, the combination of other advanced technologies has greater potential in tendon repair. Finally, the relevant patents of biodegradable electrospun scaffolds for repairing damaged tendons, as well as their clinical applications, problems in current development, and future directions are summarized. In general, the use of biodegradable electrospun fibers for tendon repair is a promising and exciting research field, but further research is needed to fully understand its potential and optimize its application in tissue engineering. |
| first_indexed | 2024-03-11T05:59:47Z |
| format | Article |
| id | doaj.art-fcc7d6c6da894500bdfdd8f892e761c3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T05:59:47Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-fcc7d6c6da894500bdfdd8f892e761c32023-11-17T13:27:22ZengMDPI AGPolymers2073-43602023-03-01156156610.3390/polym15061566Biodegradable Polymer Electrospinning for Tendon RepairmentYiming Zhang0Yueguang Xue1Yan Ren2Xin Li3Ying Liu4Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450003, ChinaSchool of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, ChinaZhejiang International Science and Technology Cooperation Base of Air Pollution and Health, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaZhejiang International Science and Technology Cooperation Base of Air Pollution and Health, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaGBA National Institute for Nanotechnology Innovation, Guangzhou 510700, ChinaWith the degradation after aging and the destruction of high-intensity exercise, the frequency of tendon injury is also increasing, which will lead to serious pain and disability. Due to the structural specificity of the tendon tissue, the traditional treatment of tendon injury repair has certain limitations. Biodegradable polymer electrospinning technology with good biocompatibility and degradability can effectively repair tendons, and its mechanical properties can be achieved by adjusting the fiber diameter and fiber spacing. Here, this review first briefly introduces the structure and function of the tendon and the repair process after injury. Then, different kinds of biodegradable natural polymers for tendon repair are summarized. Then, the advantages and disadvantages of three-dimensional (3D) electrospun products in tendon repair and regeneration are summarized, as well as the optimization of electrospun fiber scaffolds with different bioactive materials and the latest application in tendon regeneration engineering. Bioactive molecules can optimize the structure of these products and improve their repair performance. Importantly, we discuss the application of the 3D electrospinning scaffold’s superior structure in different stages of tendon repair. Meanwhile, the combination of other advanced technologies has greater potential in tendon repair. Finally, the relevant patents of biodegradable electrospun scaffolds for repairing damaged tendons, as well as their clinical applications, problems in current development, and future directions are summarized. In general, the use of biodegradable electrospun fibers for tendon repair is a promising and exciting research field, but further research is needed to fully understand its potential and optimize its application in tissue engineering.https://www.mdpi.com/2073-4360/15/6/1566electrospinningtendon repairnanofiber3D scaffoldingtendon scar healing |
| spellingShingle | Yiming Zhang Yueguang Xue Yan Ren Xin Li Ying Liu Biodegradable Polymer Electrospinning for Tendon Repairment Polymers electrospinning tendon repair nanofiber 3D scaffolding tendon scar healing |
| title | Biodegradable Polymer Electrospinning for Tendon Repairment |
| title_full | Biodegradable Polymer Electrospinning for Tendon Repairment |
| title_fullStr | Biodegradable Polymer Electrospinning for Tendon Repairment |
| title_full_unstemmed | Biodegradable Polymer Electrospinning for Tendon Repairment |
| title_short | Biodegradable Polymer Electrospinning for Tendon Repairment |
| title_sort | biodegradable polymer electrospinning for tendon repairment |
| topic | electrospinning tendon repair nanofiber 3D scaffolding tendon scar healing |
| url | https://www.mdpi.com/2073-4360/15/6/1566 |
| work_keys_str_mv | AT yimingzhang biodegradablepolymerelectrospinningfortendonrepairment AT yueguangxue biodegradablepolymerelectrospinningfortendonrepairment AT yanren biodegradablepolymerelectrospinningfortendonrepairment AT xinli biodegradablepolymerelectrospinningfortendonrepairment AT yingliu biodegradablepolymerelectrospinningfortendonrepairment |