Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma
Non-specific hyperresponsiveness of the respiratory tract mucosa makes one of the important pathophysiological mechanisms for asthma development; it is characterized by the increased active response of the efferent system to stimuli. When this occurs, it damages the alveoli surfactant which ensures...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2019-05-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1258 |
| _version_ | 1797700237826981888 |
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| author | E. A. Аkulovа O. V. Stepаnovа O. V. Lovаchevа A. A. Seyliev K. G. Shаpovаlov O. A. Rozenberg |
| author_facet | E. A. Аkulovа O. V. Stepаnovа O. V. Lovаchevа A. A. Seyliev K. G. Shаpovаlov O. A. Rozenberg |
| author_sort | E. A. Аkulovа |
| collection | DOAJ |
| description | Non-specific hyperresponsiveness of the respiratory tract mucosa makes one of the important pathophysiological mechanisms for asthma development; it is characterized by the increased active response of the efferent system to stimuli. When this occurs, it damages the alveoli surfactant which ensures the viability of local immunity of lung tissue. Chronic respiratory failure induces changes in the cardiovascular system. The course of inhalations with a native surfactant reduces the dependence on inhalation corticosteroid.The objective of the study: to assess the effect of the course of inhalations with surfactant on the cardiovascular system in patients with hormone-dependent asthma. Materials and methods: 15 patients with asthma underwent a 70-day course of inhalation with natural surfactant based on a certain regimen (25 mg per inhalation, 21 inhalations in total) in addition to the basic therapy (inhaled corticosteroids and bronchodilators). On the 1st and 70th days of the surfactant therapy course, oscillometry was performed in order to assess macrohemodynamic parameters.Results. After the course of treatment, pulse pressure was found to increase by 26% compared to the initial level (p <0.05), the cardiac index increased by 16% (p <0.05) and the linear blood flow rate went up by 20% (p <0.05). At the same time, the pulse wave velocity decreased by 15% (p <0.05), while specific vascular resistance went down by 24% (p <0.01). This suggests that clinical remission during surfactant therapy in asthma patients is accompanied by changes in the functional state of the cardiovascular system. |
| first_indexed | 2024-03-12T04:19:34Z |
| format | Article |
| id | doaj.art-fcc9317b544b49c8b83a5fb6b2ddabdd |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:19:34Z |
| publishDate | 2019-05-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-fcc9317b544b49c8b83a5fb6b2ddabdd2023-09-03T10:34:27ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062019-05-01974252910.21292/2075-1230-2019-97-4-25-291258Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthmaE. A. Аkulovа0O. V. Stepаnovа1O. V. Lovаchevа2A. A. Seyliev3K. G. Shаpovаlov4O. A. Rozenberg5ГУЗ «Краевая клиническая больница № 1» МЗ Забайкальского краяГУЗ «Краевая клиническая больница № 1» МЗ Забайкальского краяФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФФГБУ «Российский научный центр радиологии и хирургических технологий им. акад. А. М. Гранова» МЗ РФФГБОУ ВО «Читинская государственная медицинская академия» МЗ РФФГБУ «Российский научный центр радиологии и хирургических технологий им. акад. А. М. Гранова» МЗ РФNon-specific hyperresponsiveness of the respiratory tract mucosa makes one of the important pathophysiological mechanisms for asthma development; it is characterized by the increased active response of the efferent system to stimuli. When this occurs, it damages the alveoli surfactant which ensures the viability of local immunity of lung tissue. Chronic respiratory failure induces changes in the cardiovascular system. The course of inhalations with a native surfactant reduces the dependence on inhalation corticosteroid.The objective of the study: to assess the effect of the course of inhalations with surfactant on the cardiovascular system in patients with hormone-dependent asthma. Materials and methods: 15 patients with asthma underwent a 70-day course of inhalation with natural surfactant based on a certain regimen (25 mg per inhalation, 21 inhalations in total) in addition to the basic therapy (inhaled corticosteroids and bronchodilators). On the 1st and 70th days of the surfactant therapy course, oscillometry was performed in order to assess macrohemodynamic parameters.Results. After the course of treatment, pulse pressure was found to increase by 26% compared to the initial level (p <0.05), the cardiac index increased by 16% (p <0.05) and the linear blood flow rate went up by 20% (p <0.05). At the same time, the pulse wave velocity decreased by 15% (p <0.05), while specific vascular resistance went down by 24% (p <0.01). This suggests that clinical remission during surfactant therapy in asthma patients is accompanied by changes in the functional state of the cardiovascular system.https://www.tibl-journal.com/jour/article/view/1258легочный сурфактантбронхиальная астмасурфактант-терапиясердечно-сосудистая система |
| spellingShingle | E. A. Аkulovа O. V. Stepаnovа O. V. Lovаchevа A. A. Seyliev K. G. Shаpovаlov O. A. Rozenberg Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma Туберкулез и болезни лёгких легочный сурфактант бронхиальная астма сурфактант-терапия сердечно-сосудистая система |
| title | Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma |
| title_full | Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma |
| title_fullStr | Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma |
| title_full_unstemmed | Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma |
| title_short | Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma |
| title_sort | changes in hemodynamics during the course of surfactant therapy in patients with hormone dependent asthma |
| topic | легочный сурфактант бронхиальная астма сурфактант-терапия сердечно-сосудистая система |
| url | https://www.tibl-journal.com/jour/article/view/1258 |
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